Nebivolol, bucindolol, metoprolol and carvedilol are devoid of intrinsic sympathomimetic activity in human myocardium

K Brixius, A Bundkirchen, B Bölck… - British journal of …, 2001 - Wiley Online Library
The present study investigated whether or not there may be differences in the direct cardiac
actions of the novel, highly β 1 ‐selective adrenoceptor antagonist nebivolol (NEB) in …

Epidemiology and economic burden of chronic heart failure

A Bundkirchen, RHG Schwinger - European Heart Journal …, 2004 - academic.oup.com
Chronic heart failure is a major cause of morbidity and mortality in the general population.
Both, the increasing age of the population and success in the treatment of patients with acute …

β1-adrenoceptor selectivity of nebivolol and bisoprolol. A comparison of [3H] CGP 12.177 and [125I] iodocyanopindolol binding studies

A Bundkirchen, K Brixius, B Bölck, Q Nguyen… - European journal of …, 2003 - Elsevier
There is an ongoing discussion on whether or not high β 1 -adrenoceptor selectivity of β-adrenoceptor
antagonists may be favorable in the treatment of patients with heart failure. The …

Bucindolol exerts agonistic activity on the propranolol-insensitive state of β1-adrenoceptors in human myocardium

A Bundkirchen, K Brixius, B Bölck… - Journal of Pharmacology …, 2002 - ASPET
In congestive heart failure patients, treatment with β-adrenoceptor antagonists improves
symptoms and decreases mortality. However, intrinsic sympathomimetic activity of β-…

Nebivolol, carvedilol and metoprolol do not influence cardiac Ca2+ sensitivity

A Bundkirchen, K Brixius, B Bölck, U Mehlhorn… - European journal of …, 2001 - Elsevier
It has been argued that some β-adrenoceptor antagonists may directly influence myofibrillar
cross-bridge interaction in cardiac skinned fiber preparations of animal models. The present …

Lack of inverse agonistic activity of nebivolol, its D-and L-enantiomers and of in vivo metabolized nebivolol in human myocardium

A Bundkirchen, Q Nguyen, K Brixius, B Bölck… - European journal of …, 2003 - Elsevier
The pharmacological profile of nebivolol may be mediated by its enantiomers and/or its
hydroxylated metabolites. Therefore, the cardiac effects of the nebivolol enantiomers as well as …

[HTML][HTML] Reduced phagocytosis, ROS production and enhanced apoptosis of leukocytes upon alcohol drinking in healthy volunteers

…, B Xu, M Powerski, M Fachet, K Bundkirchen… - European journal of …, 2021 - Springer
Background Alcohol drinking is associated with a serious risk of developing health problems
as well as with a large number of traumatic injuries. Although chronic alcohol misuse is …

[HTML][HTML] Acute alcohol consumption increases systemic endotoxin bioactivity for days in healthy volunteers—with reduced intestinal barrier loss in female

…, A Janicova, B Xu, JT Vollrath, K Bundkirchen… - European journal of …, 2021 - Springer
Objective Trauma is the most common cause of death among young adults. Alcohol intoxication
plays a significant role as a cause of accidents and as a potent immunomodulator of the …

[HTML][HTML] PROGRESS–prospective observational study on hospitalized community acquired pneumonia

P Ahnert, P Creutz, M Scholz, H Schütte, C Engel… - BMC pulmonary …, 2016 - Springer
Background Community acquired pneumonia (CAP) is a high incidence disease resulting in
about 260,000 hospital admissions per year in Germany, more than myocardial infarction or …

THE INFLUENCE OF THE UBIQUITIN-EDITING ENZYME A20 AFTER MAJOR TRAUMA AND SUBSEQUENT REMOTE LUNG INJURY IN RELATION TO THE …

…, W Ye, M Simic, K Bundkirchen… - Orthopaedic …, 2021 - boneandjoint.org.uk
Introduction and Objective Hemorrhagic shock and fractures are the most common injuries
within multiple injured patients, inducing systemic and local inflammation in NF-kappaB-…