Quantitative bioluminescence resonance energy transfer (BRET) analysis was applied to
the study of β 1 - and β 2 -adrenergic receptor homo- and heterodimerization. To assess the …

G protein–coupled receptors (GPCRs) represent the largest family of proteins involved in
signal transduction. Here we present a bioluminescence resonance energy transfer (BRET) …

G protein-coupled receptor (GPCR) oligomerization is a growing concept that has emerged
from several studies suggesting that GPCRs can form both homo- and heterodimers. Using …

Despite the central physiological function of the myogenic response, the underlying signalling
pathways and the identity of mechanosensors in vascular smooth muscle (VSM) are still …

β 1 - and β 2 -adrenergic receptors (β 1 AR and β 2 AR) are co-expressed in numerous
tissues where they play a central role in the responses of various organs to sympathetic …

The ability of the closely related β 2 - and β 3 -adrenergic receptors (AR) to form hetero-oligomers
was assessed by bioluminescence resonance energy transfer. Quantitative …

Signaling by heptahelical G protein–coupled receptors (GPCR) regulates many vital body
functions. Consequently, dysfunction of GPCR signaling leads to pathologic states, and …

Determining the role of lipid raft nanodomains in G protein-coupled receptor signaling
remains fraught by the lack of assays directly monitoring rafts in native membranes. We thus …

Melanocortin-4 receptor (MC4R)-induced anorexigenic signaling in the hypothalamus
controls body weight and energy homeostasis. So far, MC4R-induced signaling has been …

Zn 2+ , Mg 2+ , and Ca 2+ are essential minerals required for a plethora of metabolic
processes and signaling pathways. Different categories of cation-selective channels and …