User profiles for Anand Rane
Anand RaneBuck institute for reseearch on Aging Verified email at buckinstitute.org Cited by 2944 |
Mitochondrial alpha-synuclein accumulation impairs complex I function in dopaminergic neurons and results in increased mitophagy in vivo
Alpha-synuclein is the major protein component of Lewy bodies, a cardinal pathological feature
of the degenerating Parkinsonian brain. Alpha-synuclein has been reported to be able to …
of the degenerating Parkinsonian brain. Alpha-synuclein has been reported to be able to …
Taurine deficiency as a driver of aging
Aging is associated with changes in circulating levels of various molecules, some of which
remain undefined. We find that concentrations of circulating taurine decline with aging in mice…
remain undefined. We find that concentrations of circulating taurine decline with aging in mice…
[PDF][PDF] Cellular senescence is induced by the environmental neurotoxin paraquat and contributes to neuropathology linked to Parkinson's disease
Exposure to the herbicide paraquat (PQ) is associated with an increased risk of idiopathic
Parkinson's disease (PD). Therapies based on PQ's presumed mechanisms of action have not…
Parkinson's disease (PD). Therapies based on PQ's presumed mechanisms of action have not…
[HTML][HTML] MAO-B elevation in mouse brain astrocytes results in Parkinson's pathology
Age-related increases in monoamine oxidase B (MAO-B) may contribute to neurodegeneration
associated with Parkinson's disease (PD). The MAO-B inhibitor deprenyl, a long-standing …
associated with Parkinson's disease (PD). The MAO-B inhibitor deprenyl, a long-standing …
Cellular senescence and the aging brain
Cellular senescence is a potent anti-cancer mechanism that arrests the proliferation of
mitotically competent cells to prevent malignant transformation. Senescent cells accumulate with …
mitotically competent cells to prevent malignant transformation. Senescent cells accumulate with …
Selective binding of nuclear alpha-synuclein to the PGC1alpha promoter under conditions of oxidative stress may contribute to losses in mitochondrial function …
…, S Rajagopolan, I Hanson, A Rane… - Free Radical Biology …, 2012 - Elsevier
Alpha-synuclein has been reported to be present in the nucleus and levels enhanced by
oxidative stress. Herein, we sought to investigate the mechanistic role of nuclear alpha-…
oxidative stress. Herein, we sought to investigate the mechanistic role of nuclear alpha-…
Inducible alterations of glutathione levels in adult dopaminergic midbrain neurons result in nigrostriatal degeneration
Parkinson's disease is a neurodegenerative disorder characterized by the preferential loss of
midbrain dopaminergic neurons in the substantia nigra (SN). One of the earliest detectable …
midbrain dopaminergic neurons in the substantia nigra (SN). One of the earliest detectable …
Mitochondrial quality control via the PGC1α-TFEB signaling pathway is compromised by parkin Q311X mutation but independently restored by rapamycin
Following its activation by PINK1, parkin is recruited to depolarized mitochondria where it
ubiquitinates outer mitochondrial membrane proteins, initiating lysosomal-mediated …
ubiquitinates outer mitochondrial membrane proteins, initiating lysosomal-mediated …
Mitochondrial DNA damage is associated with reduced mitochondrial bioenergetics in Huntington's disease
…, MR Castro, K Acevedo-Torres, A Rane… - Free Radical Biology …, 2012 - Elsevier
Oxidative stress and mitochondrial dysfunction have been implicated in the pathology of HD;
however, the precise mechanisms by which mutant huntingtin modulates levels of oxidative …
however, the precise mechanisms by which mutant huntingtin modulates levels of oxidative …
Sembragiline: a novel, selective monoamine oxidase type B inhibitor for the treatment of Alzheimer's disease
Monoamine oxidase B (MAO-B) has been implicated in the pathogenesis of Alzheimer’s
disease (AD) and other neurodegenerative disorders. Increased MAO-B expression in astroglia …
disease (AD) and other neurodegenerative disorders. Increased MAO-B expression in astroglia …