Orientational ordering transition in solid
…, AM Denenstein, JP McCauley Jr, AB Smith… - Physical Review Letters, 1991 - APS
Synchrotron-x-ray powder-diffraction and differential-scanning-calorimetry measurements
on solid C 60 reveal a first-order phase transition from a low-temperature simple-cubic …
on solid C 60 reveal a first-order phase transition from a low-temperature simple-cubic …
Carboxylic acid (bio) isosteres in drug design
C Ballatore, DM Huryn, AB Smith III - ChemMedChem, 2013 - Wiley Online Library
The carboxylic acid functional group can be an important constituent of a pharmacophore,
however, the presence of this moiety can also be responsible for significant drawbacks, …
however, the presence of this moiety can also be responsible for significant drawbacks, …
Conformational dynamics of single HIV-1 envelope trimers on the surface of native virions
…, J Arthos, DR Burton, WC Koff, JR Courter, AB Smith III… - Science, 2014 - science.org
The HIV-1 envelope (Env) mediates viral entry into host cells. To enable the direct imaging
of conformational dynamics within Env, we introduced fluorophores into variable regions of …
of conformational dynamics within Env, we introduced fluorophores into variable regions of …
Peptide synthesis catalyzed by an antibody containing a binding site for variable amino acids
R Hirschmann, AB Smith III, CM Taylor, PA Benkovic… - Science, 1994 - science.org
Monoclonal antibodies, induced with a phosphonate diester hapten, catalyzed the coupling
of p-nitrophenyl esters of N-acetyl valine, leucine, and phenylalanine with tryptophan amide …
of p-nitrophenyl esters of N-acetyl valine, leucine, and phenylalanine with tryptophan amide …
Ibuprofen-like activity in extra-virgin olive oil
…, D Morel, J Lin, J Pika, Q Han, CH Lee, AB Smith… - Nature, 2005 - nature.com
Newly pressed extra-virgin olive oil contains oleocanthal — a compound whose pungency
induces a strong stinging sensation in the throat, not unlike that caused by solutions of the non…
induces a strong stinging sensation in the throat, not unlike that caused by solutions of the non…
The microtubule-stabilizing agent, epothilone D, reduces axonal dysfunction, neurotoxicity, cognitive deficits, and Alzheimer-like pathology in an interventional study …
…, SX Xie, C Ballatore, AB Smith… - Journal of …, 2012 - Soc Neuroscience
Neurodegenerative tauopathies, such as Alzheimer's disease (AD), are characterized by
insoluble deposits of hyperphosphorylated tau protein within brain neurons. Increased …
insoluble deposits of hyperphosphorylated tau protein within brain neurons. Increased …
Epothilone D improves microtubule density, axonal integrity, and cognition in a transgenic mouse model of tauopathy
…, MJ James, SX Xie, C Ballatore, AB Smith… - Journal of …, 2010 - Soc Neuroscience
Neurons in the brains of those with Alzheimer's disease (AD) and many frontotemporal
dementias (FTDs) contain neurofibrillary tangles comprised of hyperphosphorylated tau protein. …
dementias (FTDs) contain neurofibrillary tangles comprised of hyperphosphorylated tau protein. …
Evolution of dithiane-based strategies for the construction of architecturally complex natural products
AB Smith, CM Adams - Accounts of chemical research, 2004 - ACS Publications
Umpolung-based strategies play a significant role in organic synthesis. Particularly important
are 1,3-dithiane linchpins, which serve as convenient acyl anion equivalents. The general …
are 1,3-dithiane linchpins, which serve as convenient acyl anion equivalents. The general …
Evolution of a gram-scale synthesis of (+)-discodermolide
AB Smith, TJ Beauchamp, MJ LaMarche… - Journal of the …, 2000 - ACS Publications
An efficient, highly convergent, stereocontrolled total synthesis of the potent antimitotic agent
(+)-discodermolide (1) has been achieved on gram scale. Key elements of the successful …
(+)-discodermolide (1) has been achieved on gram scale. Key elements of the successful …
Nonpeptidal peptidomimetics with. beta.-D-glucose scaffolding. A partial somatostatin agonist bearing a close structural relationship to a potent, selective substance P …
…, G Furst, CD Strader, AB Smith III - Journal of the …, 1992 - ACS Publications
… Sprengeler, George Furst, and Amos B. Smith, III* … (b) Renters,W. A. The Chemistry of
Antitumor Antibiotics; Wiley: New York, 1979; Vol. …
Antitumor Antibiotics; Wiley: New York, 1979; Vol. …