Decreased tenofovir diphosphate concentrations in a transgender female cohort: implications for human immunodeficiency virus preexposure prophylaxis

ML Cottrell, HMA Prince, AP Schauer… - Clinical Infectious …, 2019 - academic.oup.com
Feminizing hormone therapy (FHT) may interact with human immunodeficiency virus
preexposure prophylaxis (PrEP). We found that transgender women who took FHT exhibited a 7-…

Antiretroviral concentrations and surrogate measures of efficacy in the brain tissue and CSF of preclinical species

…, N White, L Adamson, AP Schauer, C Sykes, P Luciw… - Xenobiotica, 2019 - Taylor & Francis
Antiretroviral concentrations in cerebrospinal fluid (CSF) are used as surrogate for brain
tissue, although sparse data support this. We quantified antiretrovirals in brain tissue across …

[HTML][HTML] Pregnancy-related hormones increase UGT1A1-mediated labetalol metabolism in human hepatocytes

…, RJB Rementer, TA Miner, AP Schauer… - Frontiers in …, 2021 - frontiersin.org
Pregnancy-related hormones (PRH) are recognized as important regulators of hepatic
cytochrome P450 enzyme expression and function. However, the impact of PRH on the hepatic …

Validation of an LC–MS/MS assay to simultaneously monitor the intracellular active metabolites of tenofovir, emtricitabine, and lamivudine in dried blood spots

AP Schauer, C Sykes, ML Cottrell, H Prince… - … of pharmaceutical and …, 2018 - Elsevier
The ability to monitor adherence to antiretroviral therapy is critical for the interpretation of
outcomes from clinical studies of HIV, and for optimizing patient care. The antiretrovirals …

Pregnancy-related hormones increase nifedipine metabolism in human hepatocytes by inducing CYP3A4 expression

…, JK Fallon, C Sykes, AP Schauer… - Journal of …, 2021 - Elsevier
Pregnancy-related hormones (PRH) have emerged as key regulators of hepatic cytochrome
P450 (CYP) enzyme expression and function. The impact of PRH on protein levels of …

[HTML][HTML] Pharmacokinetic study of islatravir and etonogestrel implants in macaques

…, V Mrotz, C Forero, ML Cottrell, AP Schauer… - Pharmaceutics, 2023 - mdpi.com
The prevention of HIV and unintended pregnancies is a public health priority. Multi-purpose
prevention technologies capable of long-acting HIV and pregnancy prevention are desirable …

Antiretroviral drug concentrations in lymph nodes: a cross-species comparison of the effect of drug transporter expression, viral infection, and sex in humanized mice …

E Burgunder, JK Fallon, N White, AP Schauer… - … of Pharmacology and …, 2019 - ASPET
In a “kick and kill” strategy for human immunodeficiency virus (HIV) eradication, protective
concentrations of antiretrovirals (ARVs) in the lymph node are important to prevent vulnerable …

[HTML][HTML] Pregnancy related hormones increase CYP3A mediated buprenorphine metabolism in human hepatocytes: a comparison to CYP3A substrates nifedipine and …

MM Fashe, TA Miner, JK Fallon, AP Schauer… - Frontiers in …, 2023 - frontiersin.org
Introduction: Pregnancy increases the clearance of CYP3A4 substrate drugs and pregnancy-related
hormones (PRHs) induce hepatic CYP3A4 expression and metabolism. However, it …

A pharmacokinetic/pharmacodynamic model to predict effective HIV prophylaxis dosing strategies for people who inject drugs

…, ML Cottrell, HA Prince, C Sykes, AP Schauer… - … of Pharmacology and …, 2018 - ASPET
The goal of this work was to evaluate dosing strategies for tenofovir disoproxil fumarate (TDF),
tenofovir alafenamide (TAF), and emtricitabine (FTC) for pre-exposure prophylaxis (PrEP) …

Antiretroviral penetration across three preclinical animal models and humans in eight putative HIV viral reservoirs

…, M Kovarova, NR White, AP Schauer… - Antimicrobial Agents …, 2019 - Am Soc Microbiol
For HIV cure strategies like “kick and kill” to succeed, antiretroviral (ARV) drugs must reach
effective concentrations in putative viral reservoirs. We characterize penetration of six ARVs …