Alpha-synuclein has been reported to be present in the nucleus and levels enhanced by
oxidative stress. Herein, we sought to investigate the mechanistic role of nuclear alpha-…

Normal cellular metabolism produces oxidants that are neutralized within cells by antioxidant
enzymes and other antioxidants. An imbalance between oxidant and antioxidant has been …

The inescapable phenomenon of growth due to urbanization is witnessed by urban centres.
The rate of growth of an urban area can be attributed to a number of factors that play a …

Following its activation by PINK1, parkin is recruited to depolarized mitochondria where it
ubiquitinates outer mitochondrial membrane proteins, initiating lysosomal-mediated …

Oxidative stress and mitochondrial dysfunction have been implicated in the pathology of HD;
however, the precise mechanisms by which mutant huntingtin modulates levels of oxidative …

Monoamine oxidase B (MAO-B) has been implicated in the pathogenesis of Alzheimer’s
disease (AD) and other neurodegenerative disorders. Increased MAO-B expression in astroglia …

OBJECTIVE Idiopathic intracranial hypertension (IIH) is commonly associated with venous
sinus stenosis. In recent years, transvenous dural venous sinus stent (DVSS) insertion has …

Down syndrome (DS), caused by trisomy of human chromosome 21 (chr21), is the most
common genetic cause of intellectual disability. The Ts65Dn mouse model of DS is trisomic for …

Biometric System is used for person's recognition and identification for various applications.
The Biometric system is unimodal and multimodal biometric system. Unimodal Biometric …

Loss of parkin E3 ligase activity as a result of parkin gene mutation in rare familial forms of
Parkinson's disease (PD) has been shown to be detrimental to mitochondrial function and to …