The Au(I)-Catalyzed Intramolecular Hydroarylation of Terminal Alkynes Under Mild Conditions: Application to the Synthesis of 2H-Chromenes, Coumarins …
RS Menon, AD Findlay, AC Bissember… - The Journal of Organic …, 2009 - ACS Publications
Operationally simple Au(I)-catalyzed intramolecular hydroarylation (IMHA) reactions of terminal
alkynes that proceed in high yield and under very mild conditions are described. These …
alkynes that proceed in high yield and under very mild conditions are described. These …
[HTML][HTML] Pre-clinical evaluation of small molecule LOXL2 inhibitors in breast cancer
…, LE Leonte, M Garcia-Montolio, LB Singh, AD Findlay… - Oncotarget, 2017 - ncbi.nlm.nih.gov
Lysyl Oxidase-like 2 (LOXL2), a member of the lysyl oxidase family of amine oxidases is known
to be important in normal tissue development and homeostasis, as well as the onset and …
to be important in normal tissue development and homeostasis, as well as the onset and …
[HTML][HTML] A first-in-class pan-lysyl oxidase inhibitor impairs stromal remodeling and enhances gemcitabine response and survival in pancreatic cancer
…, SC Ritchie, KJ Murphy, M Trpceski, AD Findlay… - Nature Cancer, 2023 - nature.com
The lysyl oxidase family represents a promising target in stromal targeting of solid tumors
due to the importance of this family in crosslinking and stabilizing fibrillar collagens and its …
due to the importance of this family in crosslinking and stabilizing fibrillar collagens and its …
The lysyl oxidase like 2/3 enzymatic inhibitor, PXS‐5153A, reduces crosslinks and ameliorates fibrosis
H Schilter, AD Findlay, L Perryman… - Journal of cellular …, 2019 - Wiley Online Library
Fibrosis is characterized by the excessive deposition of extracellular matrix and crosslinked
proteins, in particular collagen and elastin, leading to tissue stiffening and disrupted organ …
proteins, in particular collagen and elastin, leading to tissue stiffening and disrupted organ …
Identification and optimization of mechanism-based fluoroallylamine inhibitors of lysyl oxidase-like 2/3
AD Findlay, JS Foot, A Buson, M Deodhar… - Journal of Medicinal …, 2019 - ACS Publications
Lysyl oxidase-like 2 (LOXL2) is a secreted enzyme that catalyzes the formation of cross-links
in extracellular matrix proteins, namely, collagen and elastin, and is indicated in fibrotic …
in extracellular matrix proteins, namely, collagen and elastin, and is indicated in fibrotic …
PXS-4681A, a potent and selective mechanism-based inhibitor of SSAO/VAP-1 with anti-inflammatory effects in vivo
…, H Schilter, A Buson, M Deodhar, AD Findlay… - … of Pharmacology and …, 2013 - ASPET
Semicarbazide-sensitive amine oxidase (SSAO), also known as vascular adhesion protein-1
(VAP-1), is a member of the copper-dependent amine oxidase family that is associated with …
(VAP-1), is a member of the copper-dependent amine oxidase family that is associated with …
[HTML][HTML] Topical application of an irreversible small molecule inhibitor of lysyl oxidases ameliorates skin scarring and fibrosis
N Chaudhari, AD Findlay, AW Stevenson… - Nature …, 2022 - nature.com
Scarring is a lifelong consequence of skin injury, with scar stiffness and poor appearance
presenting physical and psychological barriers to a return to normal life. Lysyl oxidases are a …
presenting physical and psychological barriers to a return to normal life. Lysyl oxidases are a …
Total synthesis and stereochemical reassignment of (+)-dolastatin 19
I Paterson, AD Findlay, GJ Florence - Organic Letters, 2006 - ACS Publications
A revised configurational assignment for the cytotoxic marine macrolide dolastatin 19 is
proposed and validated by total synthesis. Key features of the route include an asymmetric …
proposed and validated by total synthesis. Key features of the route include an asymmetric …
A chemoenzymatic total synthesis of (+)-amabiline
AD Findlay, MG Banwell - Organic Letters, 2009 - ACS Publications
… (-)-Amabiline [(-)-2], which was isolated during a search for new, plant-derived antimalarial
agents,2 is a further example of a crinine alkaloid and one that possesses a novel oxygenation …
agents,2 is a further example of a crinine alkaloid and one that possesses a novel oxygenation …
Total Synthesis of (−)‐Spirangien A, an Antimitotic Polyketide Isolated from the Myxobacterium Sorangium Cellulosum
I Paterson, AD Findlay, C Noti - Chemistry–An Asian Journal, 2009 - Wiley Online Library
A stereocontrolled total synthesis of the cytotoxic spiroacetal‐containing polyketide (−)‐spirangien
A is described. This utilizes an aldol‐based strategy to construct a common …
A is described. This utilizes an aldol‐based strategy to construct a common …