Windup leads to characteristics of central sensitization

J Li, DA Simone, AA Larson - Pain, 1999 - journals.lww.com
Central sensitization refers to enhanced excitability of dorsal horn neurons and is characterized
by increased spontaneous activity, enlarged receptive field (RF) areas, and an increase …

Increased concentrations of nerve growth factor in cerebrospinal fluid of patients with fibromyalgia.

SL Giovengo, IJ Russell, AA Larson - The Journal of rheumatology, 1999 - europepmc.org
Objective To determine whether there is a difference in the concentration of nerve growth
factor (NGF) in the cerebrospinal fluid (CSF) from patients diagnosed with primary fibromyalgia …

Changes in the concentrations of amino acids in the cerebrospinal fluid that correlate with pain in patients with fibromyalgia: implications for nitric oxide pathways

AA Larson, SL Giovengo, IJ Russell, JE Michalek - Pain, 2000 - Elsevier
Substance P (SP), a putative nociceptive transmitter, is increased in the CSF of patients with
fibromyalgia syndrome (FMS). Because excitatory amino acids (EAAs) also appear to …

Extracellular amino acid concentrations in the dorsal spinal cord of freely moving rats following veratridine and nociceptive stimulation

…, DH Smullin, AJ Beitz, AA Larson - Journal of …, 1988 - Wiley Online Library
In vivo microdialysis was used to sample extracellular concentrations of amino acids in the
dorsal lumbar spinal cord of freely moving rats. Changes in the extracellular concentrations of …

Neurophysiopathogenesis of fibromyalgia syndrome: a unified hypothesis

IJ Russell, AA Larson - Rheumatic Disease Clinics, 2009 - rheumatic.theclinics.com
Many contemporary and past articles dealing with the fibromyalgia syndrome (FMS) have
indicated that its pathogenesis is unknown. That statement is no longer correct and should be …

Hypothermia prevents ischemia-induced increases in hippocampal glycine concentrations in rabbits.

…, MS Scheller, SR Skilling, DH Smullin, AA Larson - Stroke, 1991 - Am Heart Assoc
We subjected 10 New Zealand White rabbits to 10 minutes of global cerebral ischemia under
either normothermic (37 degrees C) or moderately hypothermic (29 degrees C) conditions. …

Pain threshold changes in adjuvant-induced inflammation: a possible model of chronic pain in the mouse

AA Larson, DR Brown, S El-Atrash… - … Biochemistry and Behavior, 1986 - Elsevier
A chronic hyperalgesic condition was induced in mice by the injection of Freund's complete
adjuvant (FCA) into the lower lumbar region or directly into the hind footpads. Although little …

Depressive behavior in the forced swim test can be induced by TRPV1 receptor activity and is dependent on NMDA receptors

…, KJ Kovács, MG Nunez, AA Larson - Pharmacological …, 2014 - Elsevier
Blocking, desensitizing, or knocking out transient receptor potential vanilloid type 1 (TRPV1)
receptors decreases immobility in the forced swim test, a measure of depressive behavior. …

Glycine potentiates strychnine-induced convulsions: role of NMDA receptors

AA Larson, AJ Beitz - Journal of Neuroscience, 1988 - Soc Neuroscience
Strychnine poisoning leads to seizures that have traditionally been attributed to competitive
antagonism of glycine receptors in the spinal cord. Although glycine is thought to act as an …

Excitatory amino acids are released from rat primary afferent neurons in vitro

…, K Jeftinija, F Liu, SR Skilling, DH Smullin, AA Larson - Neuroscience …, 1991 - Elsevier
Multiple lines of evidence implicate the excitatory amino acids (EAAs) l-aspartate (l-Asp) and
l-glutamate (l-Glu) as excitatory transmitters in the spinal cord. The specific objective of this …