Proapoptotic protein Bim is differentially required during thymic clonal deletion to ubiquitous versus tissue-restricted antigens
AYW Suen, TA Baldwin - Proceedings of the National …, 2012 - National Acad Sciences
Positive and negative selection of thymocytes in the thymus are critical for the development
of a mature and self-tolerant T-cell repertoire. The proapoptotic Bcl-2 family member Bim is …
of a mature and self-tolerant T-cell repertoire. The proapoptotic Bcl-2 family member Bim is …
Kinetic and thermodynamic assessment of binding of serotonin transporter inhibitors
RS Martin, RA Henningsen, A Suen… - … of Pharmacology and …, 2008 - ASPET
Several serotonin reuptake inhibitors are in clinical use for treatment of depression and
anxiety disorders. However, to date, reported pharmacological differentiation of these ligands …
anxiety disorders. However, to date, reported pharmacological differentiation of these ligands …
Examination of thymic positive and negative selection by flow cytometry
Q Hu, SA Nicol, AYW Suen, TA Baldwin - JoVE (Journal of Visualized …, 2012 - jove.com
A healthy immune system requires that T cells respond to foreign antigens while remaining
tolerant to self-antigens. Random rearrangement of the T cell receptor (TCR) α and β loci …
tolerant to self-antigens. Random rearrangement of the T cell receptor (TCR) α and β loci …
Nur77 regulates nondeletional mechanisms of tolerance in T cells
QN Hu, AYW Suen, LM Henao Caviedes… - The Journal of …, 2017 - journals.aai.org
Negative selection against highly self-reactive thymocytes is critical for preventing autoimmunity.
Thymocyte deletion, anergy induction, and agonist selection are all forms of negative …
Thymocyte deletion, anergy induction, and agonist selection are all forms of negative …
[HTML][HTML] Psychometric properties of EQ-5D-5L for use in patients with Graves' disease
Background The EQ-5D-5 L is a commonly used generic measure of health. This study aimed
to evaluate the psychometric properties of the EQ-5D-5 L in patients with Graves’ disease (…
to evaluate the psychometric properties of the EQ-5D-5 L in patients with Graves’ disease (…
Establishment of CD8+ T cell thymic central tolerance to tissue-restricted antigen requires PD-1
JF May, RG Kelly, AYW Suen, J Kim, J Kim… - The Journal of …, 2024 - journals.aai.org
Highly self-reactive T cells are censored from the repertoire by both central and peripheral
tolerance mechanisms upon receipt of high-affinity TCR signals. Clonal deletion is considered …
tolerance mechanisms upon receipt of high-affinity TCR signals. Clonal deletion is considered …
Canada in a climate disrupted world
Climate change has already begun impacting economies and societies across the globe,
and its impacts are expected to increase into the future. Adaptation to climate change is and …
and its impacts are expected to increase into the future. Adaptation to climate change is and …
Political Culture: An Unexplored Factor in Climate Change Diplomacy
A Suen - 2022 - scholars.wlu.ca
As climate change continues to ravage the world, mitigation efforts continue to be insufficient
to rise to the challenge. Inaction on climate change has been traditionally explained by …
to rise to the challenge. Inaction on climate change has been traditionally explained by …
Fighting Wildfires Using UAVs Using Autonomous Biodegradable Self-sacrificing (ABS) Drones to Combat Large Wildfires with the Assistance of Satellite Imagery
…, A Gogi, S Kulkarni, B Nguyen, R Sharma, A Suen - 2023 - ntrs.nasa.gov
As wildfires continue to increase in number and severity due to global warming, firefighters
are having a harder time combating them safely. This paper examines the application of …
are having a harder time combating them safely. This paper examines the application of …
Perioperative Management of Cardiac Surgical Patients Receiving Antithrombotic Agents
P Bhuptani, ATH Suen, CD Mazer - Evidence-Based Practice in …, 2021 - Springer
The two primary classes of anti-thrombotic drugs are antiplatelet and anticoagulant agents.
Seeking an optimal balance between reducing the risk of thrombosis and minimizing the risk …
Seeking an optimal balance between reducing the risk of thrombosis and minimizing the risk …