Proapoptotic protein Bim is differentially required during thymic clonal deletion to ubiquitous versus tissue-restricted antigens

AYW Suen, TA Baldwin - Proceedings of the National …, 2012 - National Acad Sciences
Positive and negative selection of thymocytes in the thymus are critical for the development
of a mature and self-tolerant T-cell repertoire. The proapoptotic Bcl-2 family member Bim is …

Kinetic and thermodynamic assessment of binding of serotonin transporter inhibitors

RS Martin, RA Henningsen, A Suen… - … of Pharmacology and …, 2008 - ASPET
Several serotonin reuptake inhibitors are in clinical use for treatment of depression and
anxiety disorders. However, to date, reported pharmacological differentiation of these ligands …

Examination of thymic positive and negative selection by flow cytometry

Q Hu, SA Nicol, AYW Suen, TA Baldwin - JoVE (Journal of Visualized …, 2012 - jove.com
A healthy immune system requires that T cells respond to foreign antigens while remaining
tolerant to self-antigens. Random rearrangement of the T cell receptor (TCR) α and β loci …

Nur77 regulates nondeletional mechanisms of tolerance in T cells

QN Hu, AYW Suen, LM Henao Caviedes… - The Journal of …, 2017 - journals.aai.org
Negative selection against highly self-reactive thymocytes is critical for preventing autoimmunity.
Thymocyte deletion, anergy induction, and agonist selection are all forms of negative …

[HTML][HTML] Psychometric properties of EQ-5D-5L for use in patients with Graves' disease

X Liu, WWL Chan, EHM Tang, AHY Suen… - Health and Quality of …, 2023 - Springer
Background The EQ-5D-5 L is a commonly used generic measure of health. This study aimed
to evaluate the psychometric properties of the EQ-5D-5 L in patients with Graves’ disease (…

Establishment of CD8+ T cell thymic central tolerance to tissue-restricted antigen requires PD-1

JF May, RG Kelly, AYW Suen, J Kim, J Kim… - The Journal of …, 2024 - journals.aai.org
Highly self-reactive T cells are censored from the repertoire by both central and peripheral
tolerance mechanisms upon receipt of high-affinity TCR signals. Clonal deletion is considered …

Canada in a climate disrupted world

S Dalby, D Scott, C Dasilva, A Suen - 2017 - scholars.wlu.ca
Climate change has already begun impacting economies and societies across the globe,
and its impacts are expected to increase into the future. Adaptation to climate change is and …

Political Culture: An Unexplored Factor in Climate Change Diplomacy

A Suen - 2022 - scholars.wlu.ca
As climate change continues to ravage the world, mitigation efforts continue to be insufficient
to rise to the challenge. Inaction on climate change has been traditionally explained by …

Fighting Wildfires Using UAVs Using Autonomous Biodegradable Self-sacrificing (ABS) Drones to Combat Large Wildfires with the Assistance of Satellite Imagery

…, A Gogi, S Kulkarni, B Nguyen, R Sharma, A Suen - 2023 - ntrs.nasa.gov
As wildfires continue to increase in number and severity due to global warming, firefighters
are having a harder time combating them safely. This paper examines the application of …

Perioperative Management of Cardiac Surgical Patients Receiving Antithrombotic Agents

P Bhuptani, ATH Suen, CD Mazer - Evidence-Based Practice in …, 2021 - Springer
The two primary classes of anti-thrombotic drugs are antiplatelet and anticoagulant agents.
Seeking an optimal balance between reducing the risk of thrombosis and minimizing the risk …