Influence of opioid agonists on cardiac humanether-a-go-go-related gene K+ currents

AN Katchman, KA McGroary, MJ Kilborn… - … of Pharmacology and …, 2002 - ASPET
We have evaluated the ability of various opioid agonists, including methadone, l-α-acetylmethadol
(LAAM), fentanyl, meperidine, codeine, morphine, and buprenorphine, to block the …

QTc interval prolongation associated with intravenous methadone

…, G Schulman, HT Thaler, DL Keefe, AN Katchman… - Pain, 2003 - Elsevier
Numerous medications prolong the rate-corrected QT (QTc) interval and induce arrhythmias
by blocking ionic current through cardiac potassium channels composed of subunits …

Gadolinium decreases stretch-induced vulnerability to atrial fibrillation

F Bode, A Katchman, RL Woosley, MR Franz - Circulation, 2000 - Am Heart Assoc
Background—Atrial fibrillation (AF) is frequently associated with atrial dilatation caused by
pressure or volume overload. Stretch-activated channels (SACs) have been found in …

Mechanism of adrenergic CaV1.2 stimulation revealed by proximity proteomics

G Liu, A Papa, AN Katchman, SI Zakharov, D Roybal… - Nature, 2020 - nature.com
Increased cardiac contractility during the fight-or-flight response is caused by β-adrenergic
augmentation of Ca V 1.2 voltage-gated calcium channels 1 , 2 , 3 – 4 . However, this …

Gender difference in the cycle length-dependent QT and potassium currents in rabbits

XK Liu, A Katchman, MD Drici, SN Ebert, I Ducic… - … of Pharmacology and …, 1998 - ASPET
Women are known to have a longer electrocardiographic QT than men, which may
contribute to their being at greater risk of developing drug-induced polymorphic ventricular …

In vivo androgen treatment shortens the QT interval and increases the densities of inward and delayed rectifier potassium currents in orchiectomized male rabbits

XK Liu, A Katchman, BH Whitfield, G Wan… - Cardiovascular …, 2003 - academic.oup.com
Objectives: Women have longer rate-corrected QT intervals (QTc) and are at higher risk for
developing life-threatening torsades de pointes ventricular arrhythmias than men, especially …

Comparative evaluation of HERG currents and QT intervals following challenge with suspected torsadogenic and nontorsadogenic drugs

AN Katchman, J Koerner, T Tosaka, RL Woosley… - … of Pharmacology and …, 2006 - ASPET
The purpose of the present study was to comparatively evaluate human HERG currents and
QT intervals following challenge with suspected torsadogenic and nontorsadogenic drugs. …

Monophasic action potential recordings from intact mouse heart: validation, regional heterogeneity, and relation to refractoriness

BC Knollmann, AN Katchman… - Journal of …, 2001 - Wiley Online Library
MAP Recordings from Mouse Heart. Introduction: The monophasic action potential (MAP)
technique has been validated in humans and larger animals, but, in mice, MAP recordings …

[HTML][HTML] Cardiac L-type calcium channel (Cav1. 2) associates with γ subunits

L Yang, A Katchman, JP Morrow, D Doshi… - The FASEB …, 2011 - ncbi.nlm.nih.gov
The cardiac voltage-gated Ca 2+ channel, Ca v 1.2, mediates excitation-contraction coupling
in the heart. The molecular composition of the channel includes the pore-forming α1 …

[HTML][HTML] Aberrant sodium influx causes cardiomyopathy and atrial fibrillation in mice

…, J Abrams, RL Weinberg, AN Katchman… - The Journal of …, 2016 - Am Soc Clin Investig
Increased sodium influx via incomplete inactivation of the major cardiac sodium channel Na
V 1.5 is correlated with an increased incidence of atrial fibrillation (AF) in humans. Here, we …