User profiles for Alessia Ligresti
 | Alessia LigrestiVerified email at icb.cnr.it Cited by 10678 |
Cloning of the first sn1-DAG lipases points to the spatial and temporal regulation of endocannabinoid signaling in the brain
Diacylglycerol (DAG) lipase activity is required for axonal growth during development and
for retrograde synaptic signaling at mature synapses. This enzyme synthesizes the …
for retrograde synaptic signaling at mature synapses. This enzyme synthesizes the …
Effects of cannabinoids and cannabinoid‐enriched Cannabis extracts on TRP channels and endocannabinoid metabolic enzymes
L De Petrocellis, A Ligresti, AS Moriello… - British journal of …, 2011 - Wiley Online Library
BACKGROUND AND PURPOSE Cannabidiol (CBD) and Δ 9 ‐tetrahydrocannabinol (THC)
interact with transient receptor potential (TRP) channels and enzymes of the …
interact with transient receptor potential (TRP) channels and enzymes of the …
Antitumor activity of plant cannabinoids with emphasis on the effect of cannabidiol on human breast carcinoma
Δ 9 -Tetrahydrocannabinol (THC) exhibits antitumor effects on various cancer cell types, but
its use in chemotherapy is limited by its psychotropic activity. We investigated the antitumor …
its use in chemotherapy is limited by its psychotropic activity. We investigated the antitumor …
From phytocannabinoids to cannabinoid receptors and endocannabinoids: pleiotropic physiological and pathological roles through complex pharmacology
A Ligresti, L De Petrocellis… - Physiological …, 2016 - journals.physiology.org
Apart from having been used and misused for at least four millennia for, among others,
recreational and medicinal purposes, the cannabis plant and its most peculiar chemical …
recreational and medicinal purposes, the cannabis plant and its most peculiar chemical …
Possible endocannabinoid control of colorectal cancer growth
Background & Aims : The endocannabinoids anandamide and 2-arachidonoylglycerol (2-AG)
inhibit cancer cell proliferation by acting at cannabinoid receptors (CBRs). We studied (1) …
inhibit cancer cell proliferation by acting at cannabinoid receptors (CBRs). We studied (1) …
[HTML][HTML] Endocannabinoids may mediate the ability of (n-3) fatty acids to reduce ectopic fat and inflammatory mediators in obese Zucker rats
Dietary (n-3) long-chain PUFA [(n-3) LCPUFA] ameliorate several metabolic risk factors for
cardiovascular diseases, although the mechanisms of these beneficial effects are not fully …
cardiovascular diseases, although the mechanisms of these beneficial effects are not fully …
The endocannabinoid signalling system: biochemical aspects
Knowledge of the endogenous cannabinoid system has expanded greatly during the past
years. After the discovery of the cannabinoid receptors, of their endogenous agonists and of …
years. After the discovery of the cannabinoid receptors, of their endogenous agonists and of …
Non‐THC cannabinoids inhibit prostate carcinoma growth in vitro and in vivo: pro‐apoptotic effects and underlying mechanisms
L De Petrocellis, A Ligresti… - British journal of …, 2013 - Wiley Online Library
BACKGROUND AND PURPOSE Cannabinoid receptor activation induces prostate
carcinoma cell (PCC) apoptosis, but cannabinoids other than Δ 9 ‐tetrahydrocannabinol (THC), …
carcinoma cell (PCC) apoptosis, but cannabinoids other than Δ 9 ‐tetrahydrocannabinol (THC), …
Neural precursor cells induce cell death of high-grade astrocytomas through stimulation of TRPV1
Primary astrocytomas of grade 3 or 4 according to the classification system of the World
Health Organization (high-grade astrocytomas or HGAs) are preponderant among adults and …
Health Organization (high-grade astrocytomas or HGAs) are preponderant among adults and …
Adolescent exposure to THC in female rats disrupts developmental changes in the prefrontal cortex
Current concepts suggest that exposure to THC during adolescence may act as a risk factor
for the development of psychiatric disorders later in life. However, the molecular …
for the development of psychiatric disorders later in life. However, the molecular …