Increased adipose tissue lipogenesis is associated with enhanced insulin sensitivity. Mice
overexpressing the Glut4 glucose transporter in adipocytes have elevated lipogenesis and …

Despite decades of accumulated knowledge about proteins and their post-translational
modifications (PTMs), numerous questions remain regarding their molecular composition and …

The complete extent to which the human genome is translated into polypeptides is of fundamental
importance. We report a peptidomic strategy to detect short open reading frame (sORF…

Introduction Embryogenesis is thought to be directed by a small number of signaling pathways
with most if not all embryonic signals having been identified. However, the molecular …

Metabolism and ageing are intimately linked. Compared with ad libitum feeding, dietary
restriction consistently extends lifespan and delays age-related diseases in evolutionarily …

Mice use pheromones, compounds emitted and detected by members of the same species,
as cues to regulate social behaviours such as pup suckling, aggression and mating 1 . …

Metalloproteases (MPs) are a large and diverse class of enzymes implicated in numerous
physiological and pathological processes, including tissue remodeling, peptide hormone …

Although long non-coding RNAs (lncRNAs) are non-protein-coding transcripts by definition,
recent studies have shown that a fraction of putative small open reading frames within …

The origin of homochirality in living systems is often attributed to the generation of
enantiomeric differences in a pool of chiral prebiotic molecules 1 , 2 , but none of the possible …

Continuous de novo fatty acid synthesis is a common feature of cancer that is required to
meet the biosynthetic demands of a growing tumor. This process is controlled by the rate-…