Chronic inhibition of hypoxia-inducible factor prolyl 4-hydroxylase improves ventricular performance, remodeling, and vascularity after myocardial infarction in the rat
…, KJ Duffy, JL Ariazi, S Zhao, AR Olzinski… - Journal of …, 2010 - journals.lww.com
Background: Hypoxia inducible factors (HIFs) are transcription factors that are regulated by
HIF-prolyl 4-hydroxylases (PHDs) in response to changes in oxygen tension. Once activated, …
HIF-prolyl 4-hydroxylases (PHDs) in response to changes in oxygen tension. Once activated, …
Differential uptake of ferumoxtran‐10 and ferumoxytol, ultrasmall superparamagnetic iron oxide contrast agents in rabbit: critical determinants of atherosclerotic plaque …
AD Yancy, AR Olzinski, TCC Hu… - Journal of Magnetic …, 2005 - Wiley Online Library
Purpose To compare atherosclerotic plaque uptake of a first (ferumoxtran‐10) and second
generation (ferumoxytol) ultrasmall superparamagnetic iron oxide (USPIO) contrast agent with …
generation (ferumoxytol) ultrasmall superparamagnetic iron oxide (USPIO) contrast agent with …
[HTML][HTML] Comparison of soluble guanylate cyclase stimulators and activators in models of cardiovascular disease associated with oxidative stress
…, LA Morgan, K Maniscalco, AR Olzinski… - Frontiers in …, 2012 - frontiersin.org
Soluble guanylate cyclase (sGC), the primary mediator of nitric oxide (NO) bioactivity, exists
as reduced (NO-sensitive) and oxidized (NO-insensitive) forms. We tested the hypothesis …
as reduced (NO-sensitive) and oxidized (NO-insensitive) forms. We tested the hypothesis …
p38 MAPK inhibition reduces aortic ultrasmall superparamagnetic iron oxide uptake in a mouse model of atherosclerosis: MRI assessment
JB Morris, AR Olzinski, RE Bernard… - … , and vascular biology, 2008 - Am Heart Assoc
Objective— Ultrasmall superparamagnetic iron oxide (USPIO) contrast agents have been
used for noninvasive MRI assessment of atherosclerotic plaque inflammation. The purpose of …
used for noninvasive MRI assessment of atherosclerotic plaque inflammation. The purpose of …
p38 MAPK inhibitors ameliorate target organ damage in hypertension: Part 1. p38 MAPK-dependent endothelial dysfunction and hypertension
…, ME Eybye, RE Haimbach, AR Olzinski… - … of Pharmacology and …, 2003 - ASPET
Numerous mediators, believed to play a role in endothelial dysfunction (eg, neurohormones,
cytokines, hypoxia, and stretch), have been shown to activate p38 mitogen-activated …
cytokines, hypoxia, and stretch), have been shown to activate p38 mitogen-activated …
Assessment of macrophage infiltration in a murine model of abdominal aortic aneurysm
GH Turner, AR Olzinski, RE Bernard… - Journal of Magnetic …, 2009 - Wiley Online Library
Purpose To evaluate the use of an ultrasmall superparamagnetic iron oxide (USPIO)
contrast agent as a marker for the detection of macrophage in a preclinical abdominal aortic …
contrast agent as a marker for the detection of macrophage in a preclinical abdominal aortic …
Cathepsin S expression is up-regulated following balloon angioplasty in the hypercholesterolemic rabbit
CL Burns-Kurtis, AR Olzinski, S Needle… - Cardiovascular …, 2004 - academic.oup.com
Objective: Neointimal development following balloon angioplasty involves many factors
including smooth muscle cell (SMC) migration and proliferation and extracellular matrix (ECM) …
including smooth muscle cell (SMC) migration and proliferation and extracellular matrix (ECM) …
Activation of the amino acid response pathway blunts the effects of cardiac stress
…, RE Bernard, W Bao, AR Olzinski… - Journal of the …, 2017 - Am Heart Assoc
Background The amino acid response ( AAR ) is an evolutionarily conserved protective
mechanism activated by amino acid deficiency through a key kinase, general control …
mechanism activated by amino acid deficiency through a key kinase, general control …
Pharmacological inhibition of CC chemokine receptor 2 decreases macrophage infiltration in the aortic root of the human CC chemokine receptor 2/apolipoprotein E …
AR Olzinski, GH Turner, RE Bernard… - … , and vascular biology, 2010 - Am Heart Assoc
Purpose— This study assessed the pharmacological effect of a novel selective CC chemokine
receptor (CCR) 2 antagonist (GSK1344386B) on monocyte/macrophage infiltration into …
receptor (CCR) 2 antagonist (GSK1344386B) on monocyte/macrophage infiltration into …
Differential effects of p38 mitogen-activated protein kinase and cyclooxygenase 2 inhibitors in a model of cardiovascular disease
RN Willette, ME Eybye, AR Olzinski, DJ Behm… - … of Pharmacology and …, 2009 - ASPET
The evidence is compelling for a role of inflammation in cardiovascular diseases; however,
the chronic use of anti-inflammatory drugs for these indications has been disappointing. The …
the chronic use of anti-inflammatory drugs for these indications has been disappointing. The …