This study was undertaken to evaluate the direct cardioprotective effect of trimetazidine (TMZ),
an anti-anginal drug devoid of haemodynamic action, on isolated myocytes. Cultured rat …

The heart is known for its ability to produce energy from fatty acids (FA) because of its
important β-oxidation equipment, but it can also derive energy from several other substrates …

Metabolic programming and metabolic imprinting describe early life events, which impact
upon on later physiological outcomes. Despite the increasing numbers of papers and studies, …

The interrelation between iron, iron chelation, and anthracycline toxicity was investigated in
a heart cell culture system. Two indicators of cellular damage have been used, lactate …

Trimetazidine (TMZ) is an anti-ischemic compound devoid of hemodynamic effects. It was
recently suggested to induce cardiomyocyte protection by a mechanism involving lipid …

The influence of dietary n-6 and n-3 polyunsaturated fatty acids (PUFA) on heart pump
function and mitochondrial energy metabolism was investigated before and after ischemia. …

Long chain polyunsaturated fatty acids (PUFAs) play an important role in cardioprotection.
These effects have been largely attributed to membrane docosahexaenoic acid. Conversely, …

AMP-activated protein kinase (AMPK) plays an important role in controlling energy homeostasis
and is envisioned as a promising target to treat metabolic disorders. In the heart, AMPK …

The cardiovascular consequences of eicosapentaenoic acid (EPA)- and docosahexaenoic
acid (DHA)-specific intake were evaluated in vivo in a hyperinsulinemia (HI) model induced …

The effect of iron loading on membrane potential and cellular contractility was examined in
cultured heart cells obtained from newborn rat ventricles exposed to ferric ammonium citrate …