Previous studies have shown that riluzole (2-amino-6-trifluoromethoxy-benzothiazole), a drug
which interferes with glutamate neurotransmission, has a neuroprotective action in rodent …

Two series of analogues of riluzole, a blocker of excitatory amino acid mediated
neurotransmission, have been synthesized: monosubstituted 2-benzothiazolamines and 3-substituted …

The removal of lead from drinking water was investigated to develop a point-of-use water
filter that could meet the regulation imposed by the new European Directive 98-83 lowering …

Although several adaptive mechanisms have been identified that mask the existence of
Parkinson's disease and delay the onset and aggravation of motor symptoms, the timescale and …

α-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid (AMPA) glutamate receptor antagonists
are of potential interest for the treatment of certain acute and chronic neurodegenerative …

Excessive release of glutamate, a potent excitatory neurotransmitter, is thought to play an
important role in a variety of acute and chronic neurological disorders, suggesting that …

The in vivo release of 5-HT was examined in the rat brain. For this purpose, the left lateral
ventricle was perfused at a constant rate with an artificial CSF for several hours in animals …

THIS study examined high affinity Na+-dependent uptake of glutamate in synaptosomal
preparations from spinal cord in mice that express a dominant mutation of human copper/zinc …

WE have investigated whether riluzole, a compound that interferes with glutamatergic (GLUergic)
transmission, would protect central dopaminergic (DAergic) neurones from 1-methyl-4-…

Preliminary studies have shown that riluzole, a Na + channel blocker with antiglutamatergic
activity, has neuroprotective efficacy in several models of acute dopaminergic …