Elevated blood branched-chain amino acids (BCAA) are often associated with insulin
resistance and type 2 diabetes, which might result from a reduced cellular utilization and/or …

Objective Vertical sleeve gastrectomy (VSG) produces high rates of type 2 diabetes remission;
however, the mechanisms responsible remain incompletely defined. VSG increases …

Despite intensive effort and resulting gains in understanding the mechanisms underlying
neuropathic pain, limited success in therapeutic approaches have been attained. A recently …

Background & Aims Reactive oxidative species (ROS) are believed to be involved in the
progression of nonalcoholic steatohepatitis (NASH). However, little is known about the sources …

Visceral obesity has been defined as an important element of the metabolic syndrome and
contributes to the development of insulin resistance and cardiovascular disease. Increasing …

Soluble epoxide hydrolase (sEH) is a cytosolic enzyme whose inhibition has beneficial
effects in cardiovascular, inflammatory, and metabolic diseases in murine models. Mice with …

Increased permeability of the intestinal barrier is proposed as an underlying factor for
obesity-associated pathologies. Consumption of high fat diets (HFD) is associated with increased …

We investigated the capacity of dietary (−)-epicatechin (EC) to mitigate insulin resistance
through the modulation of redox-regulated mechanisms in a rat model of metabolic syndrome. …

Obesity is major public health concern worldwide and obese individuals exhibit a higher
risk of chronic diseases such as type 2 diabetes. Inflammation plays a significant role in …

Obesity constitutes a major public health concern, being frequently associated with type 2
diabetes (T2D). Evidence from studies in humans and experimental animals suggest that …