Anchoring proteins for protein kinase C: a means for isozyme selectivity

D Mochly‐Rosen, AS Gordon - The FASEB Journal, 1998 - Wiley Online Library
Protein kinase C (PKC) isozymes comprise a family of related enzymes. There are only
limited differences between these isozymes in substrate specificity or sensitivity to activators. …

Cellular and molecular neuroscience of alcoholism

I Diamond, AS Gordon - Physiological reviews, 1997 - journals.physiology.org
Recent advances in neuroscience have made it possible to investigate the pathophysiology
of alcoholism at a cellular and molecular level. Evidence indicates that ethanol affects …

Cooperative activation of dopamine D1 and D2 receptors increases spike firing of nucleus accumbens neurons via G-protein βγ subunits

FW Hopf, MG Cascini, AS Gordon… - Journal of …, 2003 - Soc Neuroscience
Dopamine in the nucleus accumbens modulates both motivational and addictive behaviors.
Dopamine D 1 and D 2 receptors are generally considered to exert opposite effects at the …

[HTML][HTML] βγ Dimers mediate synergy of dopamine D2 and adenosine A2 receptor-stimulated PKA signaling and regulate ethanol consumption

…, Z Jiang, P Fan, S Fuchs, PH Janak, AS Gordon… - Cell, 2002 - cell.com
Dopamine release is activated by ethanol and addicting drugs, but molecular mechanisms
linking dopaminergic signaling to neuronal responses and drinking behavior are poorly …

Ethanol regulation of adenosine receptor-stimulated cAMP levels in a clonal neural cell line: an in vitro model of cellular tolerance to ethanol.

AS Gordon, K Collier, I Diamond - Proceedings of the …, 1986 - National Acad Sciences
The acute and chronic neurologic effects of ethanol appear to be due to its interaction with
neural cell membranes. Chronic exposure to ethanol induces changes in the membrane that …

Ethanol Operant Self‐Administration in Rats Is Regulated by Adenosine A2 Receptors

MP Arolfo, L Yao, AS Gordon… - Alcoholism: Clinical …, 2004 - Wiley Online Library
Background: Recent findings suggest that adenosine is involved in the neural and behavioral
effects of ethanol (EtOH). Studies in neural cell culture show that EtOH, via activation of …

Chronic ethanol causes heterologous desensitization of receptors by reducing αsmessenger RNA

…, FH Chang, L Cheever, M Kim, I Diamond, AS Gordon - Nature, 1988 - nature.com
One of the biochemical results of ethanol exposure is a change in the amount of the intracellular
second messenger cyclic AMP (cAMP) produced in response to receptor stimulation 1–…

Addicting drugs utilize a synergistic molecular mechanism in common requiring adenosine and Gi-βγ dimers

…, Z Jiang, WS Mailliard, AS Gordon… - Proceedings of the …, 2003 - National Acad Sciences
The mesolimbic dopamine system and cAMP-dependent/protein kinase A (PKA) pathways
are strongly implicated in addictive behaviors. Here we determine the role of dopamine D2 …

Inhibition of adenosine uptake by ethanol is specific for one class of nucleoside transporters.

SW Krauss, RB Ghirnikar, I Diamond, AS Gordon - Molecular pharmacology, 1993 - ASPET
Adenosine uptake via nucleoside transporters is inhibited when S49 and NG108-15 cell
lines cells are exposed to ethanol. This inhibition leads to an accumulation of extracellular …

Ethanol causes translocation of cAMP-dependent protein kinase catalytic subunit to the nucleus.

…, I Diamond, AS Gordon - Proceedings of the …, 1996 - National Acad Sciences
Short- and long-term ethanol exposures have been shown to alter cellular levels of cAMP,
but little is known about the effects of ethanol on cAMP-dependent protein kinase (PKA). …