Role of haeme oxygenase‐1 in resolution of oxidative stress‐related pathologies: focus on cardiovascular, lung, neurological and kidney disorders

…, I Lekli, P Teissier, I Bak, A Tosaki - Acta …, 2012 - Wiley Online Library
The present review examines the role of the cytoprotective enzyme haeme oxygenase‐1 (HO‐1)
in adaptive responses to inflammatory disease and explores strategies for its clinical …

The biological responses to resveratrol and other polyphenols from alcoholic beverages

…, PA Kroon, DK Das, S Das, A Tosaki… - Alcoholism: Clinical …, 2009 - Wiley Online Library
Although excessive consumption of ethanol in alcoholic beverages causes multi‐organ
damage, moderate consumption, particularly of red wine, is protective against all‐cause mortality…

[HTML][HTML] Ultraviolet radiation-mediated development of cutaneous melanoma: An update

G Emri, G Paragh, Á Tósaki, E Janka, S Kollár… - … of Photochemistry and …, 2018 - Elsevier
Ultraviolet (UV) light is absorbed by nucleic acids, proteins or other endogenous chromophores,
such as porphyrins, flavins and melanin, triggering biological processes in skin cells. …

The Hill equation and the origin of quantitative pharmacology

…, A Kemeny-Beke, B Varga, B Juhasz, A Tosaki - Archive for history of …, 2012 - Springer
This review addresses the 100-year-old Hill equation (published in January 22, 1910), the
first formula relating the result of a reversible association (eg, concentration of a complex, …

Blocking acid-sensing ion channel 1 alleviates Huntington's disease pathology via an ubiquitin-proteasome system-dependent mechanism

…, C Washizu, Y Machida, A Tosaki… - Human molecular …, 2008 - academic.oup.com
Huntington's disease (HD) is a fatal neurodegenerative disorder. Despite a tremendous
effort to develop therapeutic tools in several HD models, there is no effective cure at present. …

Evaluation of the cytotoxicity of β-cyclodextrin derivatives: Evidence for the role of cholesterol extraction

T Kiss, F Fenyvesi, I Bácskay, J Váradi… - European journal of …, 2010 - Elsevier
Several β-cyclodextrin (β-CD) derivatives have been synthesized recently to improve the
physicochemical properties and inclusion capacities of the parent molecule, however, there is …

Crystal structure of an active form of BACE1, an enzyme responsible for amyloid β protein production

H Shimizu, A Tosaki, K Kaneko, T Hisano… - … and cellular biology, 2008 - Am Soc Microbiol
BACE1 (β-secretase) is a transmembrane aspartic protease that cleaves the β-amyloid
precursor protein and generates the amyloid β peptide (Aβ). BACE1 cycles between the cell …

[HTML][HTML] Grape seed proanthocyanidins improved cardiac recovery during reperfusion after ischemia in isolated rat hearts

…, I Bak, P Kovacs, D Bagchi, DK Das, A Tosaki - The American journal of …, 2002 - Elsevier
Background: Increasing evidence shows that red wine consumption has cardioprotective
effects. These effects have been attributed to the polyphenolic compounds in grapes. Objective: …

Grape seed proanthocyanidin reduces cardiomyocyte apoptosis by inhibiting ischemia/reperfusion-induced activation of JNK-1 and C-JUN

M Sato, D Bagchi, A Tosaki, DK Das - Free Radical Biology and Medicine, 2001 - Elsevier
The mechanism of cardioprotection with red wine consumption was studied by examining
the antideath signaling cascade of one of the principle components of red wine, …

[HTML][HTML] The cardioprotective effect of metformin in doxorubicin-induced cardiotoxicity: the role of autophagy

…, A Czegledi, A Gajtko, D Pituk, I Lekli, A Tosaki - Molecules, 2018 - mdpi.com
The molecular mechanisms underlying doxorubicin-induced cardiotoxicity are still being
investigated, but are known to involve oxidative stress, mitochondrial dysfunction, and the …