Role of haeme oxygenase‐1 in resolution of oxidative stress‐related pathologies: focus on cardiovascular, lung, neurological and kidney disorders
The present review examines the role of the cytoprotective enzyme haeme oxygenase‐1 (HO‐1)
in adaptive responses to inflammatory disease and explores strategies for its clinical …
in adaptive responses to inflammatory disease and explores strategies for its clinical …
The biological responses to resveratrol and other polyphenols from alcoholic beverages
Although excessive consumption of ethanol in alcoholic beverages causes multi‐organ
damage, moderate consumption, particularly of red wine, is protective against all‐cause mortality…
damage, moderate consumption, particularly of red wine, is protective against all‐cause mortality…
[HTML][HTML] Ultraviolet radiation-mediated development of cutaneous melanoma: An update
Ultraviolet (UV) light is absorbed by nucleic acids, proteins or other endogenous chromophores,
such as porphyrins, flavins and melanin, triggering biological processes in skin cells. …
such as porphyrins, flavins and melanin, triggering biological processes in skin cells. …
The Hill equation and the origin of quantitative pharmacology
This review addresses the 100-year-old Hill equation (published in January 22, 1910), the
first formula relating the result of a reversible association (eg, concentration of a complex, …
first formula relating the result of a reversible association (eg, concentration of a complex, …
Blocking acid-sensing ion channel 1 alleviates Huntington's disease pathology via an ubiquitin-proteasome system-dependent mechanism
…, C Washizu, Y Machida, A Tosaki… - Human molecular …, 2008 - academic.oup.com
Huntington's disease (HD) is a fatal neurodegenerative disorder. Despite a tremendous
effort to develop therapeutic tools in several HD models, there is no effective cure at present. …
effort to develop therapeutic tools in several HD models, there is no effective cure at present. …
Evaluation of the cytotoxicity of β-cyclodextrin derivatives: Evidence for the role of cholesterol extraction
Several β-cyclodextrin (β-CD) derivatives have been synthesized recently to improve the
physicochemical properties and inclusion capacities of the parent molecule, however, there is …
physicochemical properties and inclusion capacities of the parent molecule, however, there is …
Crystal structure of an active form of BACE1, an enzyme responsible for amyloid β protein production
H Shimizu, A Tosaki, K Kaneko, T Hisano… - … and cellular biology, 2008 - Am Soc Microbiol
BACE1 (β-secretase) is a transmembrane aspartic protease that cleaves the β-amyloid
precursor protein and generates the amyloid β peptide (Aβ). BACE1 cycles between the cell …
precursor protein and generates the amyloid β peptide (Aβ). BACE1 cycles between the cell …
[HTML][HTML] Grape seed proanthocyanidins improved cardiac recovery during reperfusion after ischemia in isolated rat hearts
Background: Increasing evidence shows that red wine consumption has cardioprotective
effects. These effects have been attributed to the polyphenolic compounds in grapes. Objective: …
effects. These effects have been attributed to the polyphenolic compounds in grapes. Objective: …
Grape seed proanthocyanidin reduces cardiomyocyte apoptosis by inhibiting ischemia/reperfusion-induced activation of JNK-1 and C-JUN
The mechanism of cardioprotection with red wine consumption was studied by examining
the antideath signaling cascade of one of the principle components of red wine, …
the antideath signaling cascade of one of the principle components of red wine, …
[HTML][HTML] The cardioprotective effect of metformin in doxorubicin-induced cardiotoxicity: the role of autophagy
…, A Czegledi, A Gajtko, D Pituk, I Lekli, A Tosaki - Molecules, 2018 - mdpi.com
The molecular mechanisms underlying doxorubicin-induced cardiotoxicity are still being
investigated, but are known to involve oxidative stress, mitochondrial dysfunction, and the …
investigated, but are known to involve oxidative stress, mitochondrial dysfunction, and the …