Liver ischemia-reperfusion injury (IRI) is an inherent feature of liver surgery and liver
transplantation in which damage to a hypoxic organ (ischemia) is exacerbated following the return …

The endoplasmic reticulum (ER) is involved in calcium homeostasis, protein folding and lipid
biosynthesis. Perturbations in its normal functions lead to a condition called endoplasmic …

In response to stress signal, nuclear factor‐erythroid 2‐related factor 2 (Nrf2) induces the
expression of target genes involved in antioxidant defense and detoxification. Nrf2 activity is …

Hepatic ischemia reperfusion injury (IRI) is an inevitable clinical problem for liver surgery.
Polyethylene glycols (PEGs) are water soluble nontoxic polymers that have proven their …

We investigated the involvement of glycogen synthase kinase-3β (GSK3β) and the voltage-dependent
anion channel (VDAC) in livers subjected to cold ischemia–reperfusion injury (I/R) …

Ischemia reperfusion injury (IRI) leads to significant tissue damage in liver surgery. Polyethylene
glycols (PEGs) are water soluble nontoxic polymers that have proved their effectiveness …

Ischemia reperfusion injury (IRI) is a primary concern in liver transplantation, especially when
steatosis is present. Acetazolamide (AZ), a specific carbonic anhydrase (CA) inhibitor, has …

The discovery of inflammasomes has enriched our knowledge in the pathogenesis of multiple
inflammatory diseases. The NLR pyrin domain-containing protein 3 (NLRP3) has emerged …

Aldehyde dehydrogenase 2 (ALDH2) is best known for its critical detoxifying role in liver
alcohol metabolism. However, ALDH2 dysfunction is also involved in a wide range of human …

AIM: Static preservation solution is critical for liver graft outcomes, especially when steatosis
is present. Institut Georges Lopez (IGL)-1 solution protects fatty livers effectively against cold …