Microbiota affects the expression of genes involved in HPA axis regulation and local metabolism of glucocorticoids in chronic psychosocial stress

M Vodička, P Ergang, T Hrnčíř, A Mikulecká… - Brain, behavior, and …, 2018 - Elsevier
The commensal microbiota affects brain functioning, emotional behavior and ACTH and
corticosterone responses to acute stress. However, little is known about the role of the …

Different effects of two N-methyl-D-aspartate receptor antagonists on seizures, spontaneous behavior, and motor performance in immature rats

P Mareš, A Mikulecká - Epilepsy & behavior, 2009 - Elsevier
Typical N-methyl-d-aspartate (NMDA) receptor antagonists exhibit anticonvulsant action
and unwanted effects, even in developing rats. Therefore, we studied the actions of the low-…

Long-term behavioral and morphological consequences of nonconvulsive status epilepticus in rats

P Kršek, A Mikulecká, R Druga, H Kubová, Z Hliňák… - Epilepsy & Behavior, 2004 - Elsevier
The aims of the present study were to ascertain whether nonconvulsive status epilepticus (NCSE)
could give rise to long-term behavioral deficits and permanent brain damage. Two …

Comorbidities of early-onset temporal epilepsy: cognitive, social, emotional, and morphologic dimensions

A Mikulecká, R Druga, A Stuchlík, P Mareš… - Experimental …, 2019 - Elsevier
Epilepsy, the most common neurologic disorder in childhood, is associated with a subset of
psychiatric dysfunctions, including cognitive deficits, and alterations in emotionality (eg, …

The effect of methamphetamine on social interaction of adult male rats

R Šlamberová, A Mikulecká, M Pometlová… - Behavioural brain …, 2010 - Elsevier
The effect of psychostimulants on social behavior still remains unclear. Therefore the aim of
the present study was to assess the effect of low doses of methamphetamine (MA) on social …

Effects of mGluR5 and mGluR1 antagonists on anxiety-like behavior and learning in developing rats

A Mikulecká, P Mareš - Behavioural brain research, 2009 - Elsevier
Antagonists of group I metabotropic receptors exhibit anxiolytic action in adult rats. In immature
animals we demonstrated anticonvulsant action of MPEP and AIDA, antagonists of group …

An animal model of nonconvulsive status epilepticus: a contribution to clinical controversies

P Kršek, A Mikulecká, R Druga, Z Hliňák, H Kubová… - …, 2001 - Wiley Online Library
Purpose: To characterize electroencephalographic and behavioral effects as well as
electrophysiologic and morphologic consequences of a subconvulsive dose of pilocarpine in …

[HTML][HTML] The GluN2B-selective antagonist Ro 25-6981 is effective against PTZ-induced seizures and safe for further development in infantile rats

P Mareš, L Kozlová, A Mikulecká, H Kubová - Pharmaceutics, 2021 - mdpi.com
The GluN2B subunit of NMDA receptors represents a perspective therapeutic target in
various CNS pathologies, including epilepsy. Because of its predominant expression in the …

[HTML][HTML] Chronic MK-801 application in adolescence and early adulthood: a spatial working memory deficit in adult Long-Evans rats but no changes in the …

…, K Vales, H Kubova, A Mikulecka… - Frontiers in …, 2018 - frontiersin.org
The role of NMDA receptors in learning, memory and hippocampal function has long been
recognized. Post-mortem studies have indicated that the expression or subunit composition of …

[HTML][HTML] Regulation of 11β-hydroxysteroid dehydrogenase type 1 and 7α-hydroxylase CYP7B1 during social stress

M Vodička, P Ergang, A Mikulecka, L Řeháková… - PLoS …, 2014 - journals.plos.org
11β-hydroxysteroid dehydrogenase type 1 (11HSD1) is an enzyme that amplifies intracellular
glucocorticoid concentration by the conversion of inert glucocorticoids to active forms and …