User profiles for A. Losada

Andres Losada Baltar

Professor - Universidad Rey Juan Carlos). Catedrático de Psicología Clínica
Verified email at urjc.es
Cited by 7565

Dynamic molecular linkers of the genome: the first decade of SMC proteins

A Losada, T Hirano - Genes & development, 2005 - genesdev.cshlp.org
Structural maintenance of chromosomes (SMC) proteins are chromosomal ATPases, highly
conserved from bacteria to humans, that play fundamental roles in many aspects of higher-…

Cohesin in cancer: chromosome segregation and beyond

A Losada - Nature Reviews Cancer, 2014 - nature.com
Cohesin is an evolutionarily conserved, four-subunit complex that entraps DNA fibres within
its ring-shaped structure. It was originally identified and named for its role in mediating sister …

[HTML][HTML] Psychological interventions for dementia caregivers: What we have achieved, what we have learned

ST Cheng, A Au, A Losada, LW Thompson… - Current psychiatry …, 2019 - Springer
With the rising dementia population, more and more programs have been developed to help
caregivers deal with the care-recipient as well as their own frustrations. Many interventions …

Prevalence of SARS-CoV-2 in Spain (ENE-COVID): a nationwide, population-based seroepidemiological study

…, MR González, MSB Lobeiras, AF Losada… - The Lancet, 2020 - thelancet.com
Background Spain is one of the European countries most affected by the COVID-19 pandemic.
Serological surveys are a valuable tool to assess the extent of the epidemic, given the …

[HTML][HTML] Differential contributions of condensin I and condensin II to mitotic chromosome architecture in vertebrate cells

T Ono, A Losada, M Hirano, MP Myers, AF Neuwald… - Cell, 2003 - cell.com
The canonical condensin complex (henceforth condensin I) plays an essential role in mitotic
chromosome assembly and segregation from yeast to humans. We report here the …

Identification of Xenopus SMC protein complexes required for sister chromatid cohesion

A Losada, M Hirano, T Hirano - Genes & development, 1998 - genesdev.cshlp.org
The structural maintenance of chromosomes (SMC) family is a growing family of chromosomal
ATPases. The founding class of SMC protein complexes, condensins, plays a central role …

Plitidepsin has potent preclinical efficacy against SARS-CoV-2 by targeting the host protein eEF1A

…, K Obernier, M Dejosez, MJ Guillén, A Losada… - Science, 2021 - science.org
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) viral proteins interact with
the eukaryotic translation machinery, and inhibitors of translation have potent antiviral effects. …

Condensin and cohesin display different arm conformations with characteristic hinge angles

DE Anderson, A Losada, HP Erickson… - The Journal of cell …, 2002 - rupress.org
Structural maintenance of chromosomes (SMC) proteins play central roles in higher-order
chromosome dynamics from bacteria to humans. In eukaryotes, two different SMC protein …

Recurrent inactivation of STAG2 in bladder cancer is not associated with aneuploidy

…, S Chanock, S Heath, A Valencia, A Losada… - Nature …, 2013 - nature.com
Urothelial bladder cancer (UBC) is heterogeneous at the clinical, pathological and genetic
levels. Tumor invasiveness (T) and grade (G) are the main factors associated with outcome …

Identification and Characterization of Sa/Scc3p Subunits in the Xenopus and Human Cohesin Complexes

A Losada, T Yokochi, R Kobayashi… - The Journal of cell biology, 2000 - rupress.org
A multisubunit protein complex, termed cohesin, plays an essential role in sister chromatid
cohesion in yeast and in Xenopus laevis cell-free extracts. We report here that two distinct …