Calcium is a ubiquitous second messenger controlling a broad range of cellular functions
including growth and proliferation. Quiescent, hyperthrophic and proliferating cells have …

We studied the effect of chronic mechanical overloading on the isoenzyme composition of rat
cardiac myosin in several experimental models: aortic stenosis (AS), aortic incompetence (…

Ca 2+ , the main second messenger, is central to the regulation of cellular growth. There is
increasing evidence that cellular growth and proliferation are supported by a continuous store…

cAMP is one of the most important second messenger in the heart. The discovery of Epac as
a guanine exchange factor (GEF), which is directly activated by cAMP, raises the question of …

Background— Cardiomyocytes use Ca 2+ not only in excitation-contraction coupling but also
as a signaling molecule promoting, for example, cardiac hypertrophy. It is largely unclear …

Heart failure (HF) is a major health problem in Western countries. Despite significant progress
in pharmacological and device-based treatment, the disease burden imposed continues …

Myocardial ischemic disease is the major cause of death worldwide. After myocardial infarction,
reperfusion of infracted heart has been an important objective of strategies to improve …

Aging is the main risk factor for cardiovascular diseases, but the associated molecular
mechanisms are poorly understood. The Wnt signaling pathway was shown to be induced during …

The second messengers cAMP and cGMP can be degraded by specific members of the
phosphodiesterase superfamily or by active efflux transporters, namely the multidrug resistance-…

Aims Our aim was to identify new microRNAs (miRNAs) implicated in pathological vascular
smooth muscle cells (VSMCs) proliferation and characterize their mechanism of action. …