User profiles for A. Leslie Morrow

A Leslie Morrow

University of North Carolina School of Medicine
Verified email at med.unc.edu
Cited by 18029

The role of GABAA receptors in the acute and chronic effects of ethanol

AC Grobin, DB Matthews, LL Devaud, AL Morrow - Psychopharmacology, 1998 - Springer
GABA A receptors are sensitive to ethanol in distinct brain regions and are clearly involved
in the acute actions of ethanol, ethanol tolerance, ethanol dependence and ethanol self-…

Stress-induced elevations of gamma-aminobutyric acid type A receptor-active steroids in the rat brain.

RH Purdy, AL Morrow, PH Moore Jr… - Proceedings of the …, 1991 - National Acad Sciences
A 3 alpha-hydroxy A-ring-reduced metabolite of progesterone, 3 alpha-hydroxy-5 alpha-pregnan-20-one
(allopregnanolone), and one of deoxycorticosterone (DOC), 3 alpha,21-…

Allopregnanolone levels and reactivity to mental stress in premenstrual dysphoric disorder

…, PA Straneva, KC Light, CA Pedersen, AL Morrow - Biological …, 2001 - Elsevier
Background: This study was designed to examine basal and stress-induced levels of the
neuroactive progesterone metabolite, allopregnanolone, in women with premenstrual …

Neuroactive steroid 3α-hydroxy-5α-pregnan-20-one modulates electrophysiological and behavioral actions of ethanol

…, AC Grobin, LL Devaud, AL Morrow - Journal of …, 2000 - Soc Neuroscience
Neuroactive steroids are synthesized de novo in brain, yet their physiological significance
remains elusive. We provide biochemical, electrophysiological, and behavioral evidence that …

[PDF][PDF] Characterization of alpha 1-adrenergic receptor subtypes in rat brain: a reevaluation of [3H] WB4104 and [3H] prazosin binding.

AL Morrow, I Creese - Molecular pharmacology, 1986 - Citeseer
[3H] Prazosin and [3H] WB41 01 [2-(2, 6-dimethoxyphenoxyethyI) aminomethyl-1, 4 benzodioxanel
have both been proposed to label a1-adrenergic receptors in the rat central nervous …

GABAA receptor α1 subunit deletion prevents developmental changes of inhibitory synaptic currents in cerebellar neurons

…, K Prybylowski, J Kralic, AL Morrow… - Journal of …, 2001 - Soc Neuroscience
Developmental changes in miniature IPSC (mIPSC) kinetics have been demonstrated
previously in cerebellar neurons in rodents. We report that these kinetic changes in mice are …

Bidirectional Alterations of GABAA Receptor Subunit Peptide Levels in Rat Cortex During Chronic Ethanol Consumption and Withdrawal

…, JM Fritschy, W Sieghart, AL Morrow - Journal of …, 1997 - Wiley Online Library
The pharmacological properties of γ‐aminobutyric acid A (GABA A ) receptors are altered
by prolonged exposure to ethanol both in vivo and in vitro. We have shown previously that …

Synthesis, metabolism, and pharmacological activity of 3. alpha.-hydroxy steroids which potentiate GABA-receptor-mediated chloride ion uptake in rat cerebral cortical …

RH Purdy, AL Morrow, JR Blinn… - Journal of medicinal …, 1990 - ACS Publications
3a R= H 4a R= H 3b R= COCH3 4b R= COCH3 mone metabolites and other closely related
compounds,(2) to prepare the tritiated forms of the natural steroids in order to investigate …

Effects of ethanol on ion channels

FT Crews, AL Morrow, H Criswell, G Breese - International review of …, 1996 - Elsevier
Publisher Summary This chapter discusses the effect of ethanol on ion channels. Ion
channels play critical roles in nervous system function from initiating rapid synaptic activity to …

The role of GABAA receptors in the acute and chronic effects of ethanol: a decade of progress

…, JL Diaz-Granados, RS Helfand, AL Morrow - …, 2009 - Springer
The past decade has brought many advances in our understanding of GABA A receptor-mediated
ethanol action in the central nervous system. We now know that specific GABA A …