Receptor-independent fluid-phase macropinocytosis promotes arterial foam cell formation and atherosclerosis

…, J Zhou, J White, AM Stranahan, A Jasztal… - Science translational …, 2022 - science.org
Accumulation of lipid-laden foam cells in the arterial wall plays a central role in atherosclerotic
lesion development, plaque progression, and late-stage complications of atherosclerosis. …

Degradation of glycocalyx and multiple manifestations of endothelial dysfunction coincide in the early phase of endothelial dysfunction before atherosclerotic plaque …

…, J Suraj, B Proniewski, A Jasztal… - Journal of the …, 2019 - Am Heart Assoc
Background The impairment of endothelium‐dependent vasodilation, increased endothelial
permeability, and glycocalyx degradation are all important pathophysiological components …

In Vivo Magnetic Resonance Imaging‐Based Detection of Heterogeneous Endothelial Response in Thoracic and Abdominal Aorta to Short‐Term High‐Fat Diet …

…, K Matyjaszczyk‐Gwarda, A Jasztal… - Journal of the …, 2020 - Am Heart Assoc
Background Long‐term feeding with a high‐fat diet (HFD) induces endothelial dysfunction
in mice, but early HFD‐induced effects on endothelium have not been well characterized. …

Visualization of the biochemical markers of atherosclerotic plaque with the use of Raman, IR and AFM

…, TP Wrobel, A Rygula, E Maslak, A Jasztal… - Journal of …, 2014 - Wiley Online Library
In this work, we describe a methodology to visualize the biochemical markers of atherosclerotic
plaque in cross sections of brachiocephalic arteries (BCA) taken from ApoE/LDLR –/– …

[HTML][HTML] Alterations in arginine and energy metabolism, structural and signalling lipids in metastatic breast cancer in mice detected in plasma by targeted …

K Kus, A Kij, A Zakrzewska, A Jasztal, M Stojak… - Breast Cancer …, 2018 - Springer
Background The early detection of metastasis based on biomarkers in plasma may improve
cancer prognosis and guide treatment. The aim of this work was to characterize alterations …

[HTML][HTML] Nitric oxide deficiency and endothelial–mesenchymal transition of pulmonary endothelium in the progression of 4T1 metastatic breast cancer in mice

…, D Kaczor, M Stojak, E Buczek, A Jasztal… - Breast Cancer …, 2018 - Springer
Background Mesenchymal transformation of pulmonary endothelial cells contributes to the
formation of a metastatic microenvironment, but it is not known whether this precedes or …

Increased activity of vascular adenosine deaminase in atherosclerosis and therapeutic potential of its inhibition

…, L Mateuszuk, P Zukowska, A Jasztal… - Cardiovascular …, 2016 - academic.oup.com
Aims Extracellular nucleotides and adenosine that are formed or degraded by membrane-bound
ecto-enzymes could affect atherosclerosis by regulating the inflammation and …

Pathological changes in the biochemical profile of the liver in atherosclerosis and diabetes assessed by Raman spectroscopy

K Kochan, KM Marzec, K Chruszcz-Lipska, A Jasztal… - Analyst, 2013 - pubs.rsc.org
… Marzec b , Katarzyna Chruszcz-Lipska b , Agnieszka Jasztal b , Edyta Maslak b , Hanna
Musiolik a , Stefan Chłopicki bc and Malgorzata Baranska * ab …

[HTML][HTML] MRI-based in vivo detection of coronary microvascular dysfunction before alterations in cardiac function induced by short-term high-fat diet in mice

G Kwiatkowski, A Bar, A Jasztal, S Chłopicki - Scientific Reports, 2021 - nature.com
Endothelial dysfunction is one of the hallmarks of vascular abnormalities in metabolic diseases
and has been repeatedly demonstrated in coronary and peripheral circulation in mice fed …

Proteomic characterization of early lung response to breast cancer metastasis in mice

…, A Zakrzewska, M Stojak, M Sternak, A Jasztal… - Experimental and …, 2019 - Elsevier
Introduction The tumor-promoting rearrangement of the lungs facilitates the process of cancer
cell survival in a foreign microenvironment and enables their protection against immune …