A new approach to preclinical pharmacodynamic investigations is presented which allows,
in addition to information on the nature of the pharmacological properties of new chemical …

ABBREVIATIONS: P17, pentylenetetrazol; TLS, threshold for localized seizure activity; TGS,
threshold for generalized seizure activity; CL, clearance; Vdss, volume of distribution at …

The threshold for convulsions in rats can be determined by applying ramp-shaped pulse trains
directly to the cerebral cortex in rats, which provides a convenient model for investigating …

In 18 trials on grassland throughout the Netherlands sown on a soil low in organic matter,
organic matter started accumulating soon after sowing and usually continued for a long time …

In this investigation a newly developed direct cortical stimulation technique was evaluated
for measurement of anticonvulsant efficacy in rats. The kinetics of drug action for …

The purpose of this study was to assess the concentration–anti-convulsant effect relationships
of a number of anti-convulsant drugs in the direct cortical stimulation model, to obtain …

1 The purpose of this investigation was to examine the influence of increasing age on the
pharmacokinetics and the time course of the anticonvulsant response of oxazepam in BN/BiRij …

The number and biomass of earthworms in grassland may vary widely in space as well as
temporally. In old grassland in the Netherlands, numbers normally range from 300 to 900 m -2 …

The aim of the present investigations was to study the influence of increasing age on the
pharmacodynamics of valproate in BN/BiRij rats, applying a threshold for electrically induced …

In preclinical drug development power spectral analysis of drug induced changes in the
electroencephalogram (EEG) is often used to characterize the pharmacological properties of …