Age-associated changes to the mammalian DNA methylome are well documented and thought
to promote diseases of aging, such as cancer. Recent studies have identified collections …

Foresight has evolved as a distinct prospective analytical tool: it considers alternative futures
of various S&T fields or socio-economic systems by bringing together the perspectives of …

This paper reflects on the potential of future-oriented analysis (FTA) to address major change
and to support decision-makers and other stakeholders in anticipating and dealing with …

Much of the impetus comes from public sentiment, which is ever less tolerant of bank
failures and the use of public money to salvage them. Most parts of the prudential regulatory …

Cellular senescence plays a causal role in ageing and, in mice, depletion of p16 INK4a -expressing
senescent cells delays ageing-associated disorders 1 , 2 . Adenosine deaminases …

This article reviews various approaches to measuring business innovation with the aim of
drawing lessons for measuring social innovations, and offers several methodological and …

Methods This prospective, randomized, multicentre study of 11 ICUs involved 200 mixed
postoperative hypovolaemic patients (50 patients per group) in Hungary. Patients received 10 …

Cellular senescence is a stable form of cell cycle arrest associated with proinflammatory
responses. Senescent cells can be cleared by the immune system as a part of normal tissue …

Central Europe’s unique history together with its geographical location provide an excellent
opportunity to analyse the dynamics of inter-and intra-regional division of labour, the role …

Many cancers show an increase in incidence with age, and age is the biggest single risk factor
for many cancers. However, the molecular basis of this relationship is poorly understood. …