A principal challenge currently facing biologists is how to connect the complete DNA sequence
of an organism to its development and behaviour. Large-scale targeted-deletions have …

Diastolic heart failure (DHF) currently accounts for more than 50% of all heart failure patients.
DHF is also referred to as heart failure with normal left ventricular (LV) ejection fraction (…

Complete genomic sequence is known for two multicellular eukaryotes, the nematode
Caenorhabditis elegans and the fruit fly Drosophila melanogaster , and it will soon be known for …

Making a firm diagnosis of chronic heart failure with preserved ejection fraction (HFpEF)
remains a challenge. We recommend a new stepwise diagnostic process, the ‘HFA–PEFF …

RNA-binding proteins are key regulators of gene expression, yet only a small fraction have
been functionally characterized. Here we report a systematic analysis of the RNA motifs …

Regulation of body fat storage involves signalling between centres that regulate feeding in
the brain and sites of fat storage and use in the body 1 , 2 . Here we describe an assay for …

To explore the role of mitochondrial activity in the aging process, we have lowered the activity
of the electron transport chain and adenosine 5′-triphosphate (ATP) synthase with RNA …

We report a systematic RNA interference (RNAi) screen of 5,690 Caenorhabditis elegans
genes for gene inactivations that increase lifespan. We found that genes important for …

… For studies by Fraser and colleagues 16 and Korelitz and colleagues, 17 we reanalysed
the primary data to calculate the SIRs. For the study by Fraser and colleagues, 16 we used the …

The EACVI/ASE/Industry Task Force to standardize deformation imaging prepared this
consensus document to standardize definitions and techniques for using two-dimensional (2D) …