High levels of fatty acids delay the recoveryof intracellular pH and cardiac efficiency inpost-ischemic hearts by inhibiting glucose oxidation
Q Liu, JC Docherty, JCT Rendell, AS Clanachan… - Journal of the American …, 2002 - jacc.org
Objectives : This study was designed to determine if the fatty acid-induced increase in H +
production from glycolysis uncoupled from glucose oxidation delays the recovery of …
production from glycolysis uncoupled from glucose oxidation delays the recovery of …
Characterization of 5′ AMP-activated protein kinase activity in the heart and its role in inhibiting acetyl-CoA carboxylase during reperfusion following ischemia
…, L Kung, LA Witters, R Schulz, AS Clanachan… - … et Biophysica Acta (BBA …, 1996 - Elsevier
Despite the high expression of 5′AMP activated protein kinase (AMPK) in heart, the activity
and function of this enzyme in heart muscle has not been characterized. We demonstrate …
and function of this enzyme in heart muscle has not been characterized. We demonstrate …
Cardiac efficiency is improved after ischemia by altering both the source and fate of protons
B Liu, AS Clanachan, R Schulz… - Circulation research, 1996 - Am Heart Assoc
Cardiac efficiency is decreased in hearts after severe ischemia. We determined whether
reducing the production of H + from glucose metabolism or inhibiting the clearance of H + via …
reducing the production of H + from glucose metabolism or inhibiting the clearance of H + via …
Contribution of Protons to Post‐Ischemic Na+ and Ca2+ Overload and Left Ventricular Mechanical Dysfunction
AS Clanachan - Journal of cardiovascular electrophysiology, 2006 - Wiley Online Library
The intracellular accumulation of Na + and Ca 2+ plays a key role in ischemia‐induced
myocardial injury that may be manifest as left ventricular (LV) mechanical dysfunction, …
myocardial injury that may be manifest as left ventricular (LV) mechanical dysfunction, …
Anesthetic cardioprotection in clinical practice from proof-of-concept to clinical applications
…, S Behmanesh, AS Clanachan - Current …, 2014 - ingentaconnect.com
In 2007, the American Heart Association (AHA) recommended (class IIa, level of evidence B)
in their guidelines on Perioperative Cardiovascular Evaluation and Care for Noncardiac …
in their guidelines on Perioperative Cardiovascular Evaluation and Care for Noncardiac …
Stimulation of glucose oxidation protects against acute myocardial infarction and reperfusion injury
…, JS Jaswal, RA Harris, AS Clanachan… - Cardiovascular …, 2012 - academic.oup.com
Aims During reperfusion of the ischaemic myocardium, fatty acid oxidation rates quickly recover,
while glucose oxidation rates remain depressed. Direct stimulation of glucose oxidation …
while glucose oxidation rates remain depressed. Direct stimulation of glucose oxidation …
Remote ischemic preconditioning applied during isoflurane inhalation provides no benefit to the myocardium of patients undergoing on-pump coronary artery bypass …
…, J Feng, H Freidank, AS Clanachan… - The Journal of the …, 2012 - pubs.asahq.org
Background Two preconditioning stimuli should induce a more consistent overall cell protection.
We hypothesized that remote ischemic preconditioning (RIPC, second preconditioning …
We hypothesized that remote ischemic preconditioning (RIPC, second preconditioning …
Pressure-overload-induced heart failure induces a selective reduction in glucose oxidation at physiological afterload
…, J Mori, R Basu, Z Kassiri, A Clanachan… - Cardiovascular …, 2013 - academic.oup.com
Aims Development of heart failure is known to be associated with changes in energy substrate
metabolism. Information on the changes in energy substrate metabolism that occur in …
metabolism. Information on the changes in energy substrate metabolism that occur in …
Fatty acid oxidation inhibitors in the management of chronic complications of atherosclerosis
CDL Folmes, AS Clanachan, GD Lopaschuk - Current atherosclerosis …, 2005 - Springer
Ischemic heart disease is characterized by a modification of the normal energy balance of
the heart. During and following an ischemic event, circulating fatty acids are elevated, …
the heart. During and following an ischemic event, circulating fatty acids are elevated, …
Ranolazine decreases diastolic calcium accumulation caused by ATX-II or ischemia in rat hearts
Cardiac pathologies are associated with increased late I Na that contributes to the dysregulation
of ion homeostasis and causes electrical and contractile dysfunction. This study was …
of ion homeostasis and causes electrical and contractile dysfunction. This study was …