Cellular senescence, which is associated with aging, is a process by which cells enter a
state of permanent cell cycle arrest, therefore constituting a potent tumor suppressive …

Cellular senescence suppresses cancer by stably arresting the proliferation of damaged cells
1 . Paradoxically, senescent cells also secrete factors that alter tissue microenvironments 2 …

The TOR (target of rapamycin) kinase limits longevity by poorly understood mechanisms.
Rapamycin suppresses the mammalian TORC1 complex, which regulates translation, and …

DNA damage can induce a tumor suppressive response termed cellular senescence.
Damaged senescent cells permanently arrest growth, secrete inflammatory cytokines and other …

Cellular senescence irreversibly arrests proliferation in response to potentially oncogenic
stress. Senescent cells also secrete inflammatory cytokines such as IL-6, which promote age-…

Telomeres are protective structures at chromosome ends and are crucial for genomic stability.
Mammalian TRF1 and TRF2 bind the double-stranded telomeric repeat sequence and in …

Neurodegeneration is a major age-related pathology. Cognitive decline is characteristic of
patients with Alzheimer’s and related dementias and cancer patients after chemo- or radio-…

Exposure of MCF-7 breast tumor cells or HCT-116 colon carcinoma cells to clinically relevant
concentrations of doxorubicin (Adriamycin; Farmitalia Research Laboratories, Milan, Italy) …

These findings identify chemotherapy-induced senescence as a culprit behind tumor
promotion, suggesting that elimination of senescent cells after chemotherapy may reduce …

Processes that have been linked to aging and cancer include an inflammatory milieu driven
by senescent cells. Senescent cells lose the ability to divide, essentially irreversibly, and …