Involuntary movements, or dyskinesia, represent a debilitating complication of levodopa (L-dopa)
therapy for Parkinson's disease (PD). L-dopa-induced dyskinesia (LID) are ultimately …

Despite the rapid contemporary advances in neuroscience, it is generally true to say that
disorders of movement associated with basal ganglia disease remain a practical problem for …

… Mitchell IJ, Jackson A, Sambrook MA, Crossman AR. The role of the subthalamic nucleus
in … Mitchell IJ, Jackson A, Sambrook MA, Crossman AR. Common neural mechanisms in …

Central to the neural mechanism of MPTP‐induced parkinsonism is overactivity of the
subthalamic nucleus. Lesion of the subthalamic nucleus has therefore been performed in two …

The concept of a threshold of dopamine (DA) depletion for onset of Parkinson's disease
symptoms, although widely accepted, has, to date, not been determined experimentally in …

The 2-deoxyglucose metabolic mapping technique has been used to investigate the neural
mechanisms which underlie the symptoms of Parkinsonism in the 1-methyl-4-phenyl-1,2,3,6-…

… The right of Alan Crossman and David Neary to be identified as authors of this work has
been asserted by them in accordance with the Copyright, Designs and Patents Act 1988. …

The lateral segment of the globus pallidus (GPl) is thought to be overactive in levodopa-induced
dyskinesia in PD. Stimulation of cannabinoid receptors in the GPl reduces γ-…

In recent years, cannabinoid receptors and their endogenous ligands (endocannabinoids)
have been identified within the brain. The high density of CB1 cannabinoid receptors within …

The efferent connections of the brain stem nucleus tegmenti pedunculopontinus were
studied in the rat using the techniques of anterograde and retrograde transport of the enzyme …