The Wnt/β-catenin pathway, which signals through the Frizzled (Fzd) receptor family and
several coreceptors, has long been implicated in cancer. Here we demonstrate a therapeutic …

The natriuretic peptides, including human B-type natriuretic peptide (BNP), have been
implicated in the regulation of cardiac remodeling. Because transforming growth factor-β (TGF-β) …

The use of cDNA microarrays has made it possible to simultaneously analyze gene expression
for thousands of genes. Microarray technology was used to evaluate the expression of >…

The Notch signalling pathway mediates cell fate decisions 1 , 2 and is tumour suppressive
or oncogenic depending on the context 2 , 3 . During lung development, Notch pathway …

Inhibitors of angiogenic factors are known to be upregulated, and their levels increase in the
maternal circulation before the onset of preeclampsia. We reproduced a previously …

Pulmonary fibrosis is characterized by chronic scar formation and deposition of extracellular
matrix, resulting in impaired lung function and respiratory failure. Idiopathic pulmonary …

Purpose: The Notch pathway plays an important role in both stem cell biology and cancer.
Dysregulation of Notch signaling has been reported in several human tumor types. In this …

MDS is characterized by ineffective hematopoiesis that leads to peripheral cytopenias.
Development of effective treatments has been impeded by limited insight into pathogenic …

Purpose Adenoid cystic carcinomas (ACCs) represent a heterogeneous group of
chemotherapy refractory tumors, with a subset demonstrating an aggressive phenotype. We …

Purpose: Wnt signaling is implicated in tumor cell dedifferentiation and cancer stem cell
function. Ipafricept (OMP-54F28) is a first-in-class recombinant fusion protein with the …