The indole moiety is one of the most widespread heterocycles found in both natural products
and biological systems. Indoles have important biological activities including anticancer, …

Slit–Roundabout (Robo) signalling has a well-understood role in axon guidance 1 , 2 , 3 , 4
, 5 . Unlike in the nervous system, however, Slit-dependent activation of an endothelial-…

Caffeine, an adenosine A 1 , A 2A , and A 2B receptor antagonist, is frequently used as an
adjuvant analgesic in combination with nonsteroidal anti-inflammatory drugs or opioids. In this …

Hybrid molecules have become a well-established and powerful biologically relevant
heterocycles. They constitute a core structure due to their widespread use in pharmaceutical and …

3-Unsubstituted xanthine derivatives bearing a cyclopentyl or a phenyl residue in the 8-position
were synthesized and developed as A 2B adenosine receptor antagonists. Compounds …

One of the helpful ways to improve the effectiveness of anticancer agents and weaken drug
resistance is to use hybrid molecules. therefore, the current study intended to introduce 20 …

Thiazolidinedione (TZD) is one of the privileged heterocyclic rings and has shown many
biological applications in medicinal chemistry and drug discovery. This review covers the …

A series of novel xanthine/NO donor hybrids containing 1,3,8-trisubstituted or 1,8-disubstituted
xanthine derivatives were designed and synthesized. The synthesized compounds were …

A novel series of pyrimido[5,4-c]quinoline derivatives variously substituted at positions 2 and
5 have been synthesized, in good to excellent yields, via rapid base-catalyzed cyclization …

A molecularly imprinted electrochemical sensor was fabricated for sensitive and selective
detection of anti-COVID 19 drug favipiravir (FAV). The sensor is based on the synthesis of …