Clinical trials report that the class of drugs known as statins may be neuroprotective in
Alzheimer's and Parkinson's disease, and further trials are currently underway to test whether …

Inflammatory processes are a hallmark of many chronic diseases including Alzheimer's
disease and diabetes mellitus. Fairly recent statistical evidence indicating that type 2 diabetes …

Alzheimer’s disease (AD), the most common form of dementia, currently affects 40–50 million
people worldwide. Despite the extensive research into amyloid β (Aβ) deposition and tau …

Ferroptosis has been defined as an oxidative and iron-dependent pathway of regulated cell
death that is distinct from caspase-dependent apoptosis and established pathways of death …

Evolving concepts on Parkinson’s disease (PD) pathology suggest that α-synuclein (aSYN)
promote dopaminergic neuron dysfunction and death through accumulating in the …

The crosstalk between different organelles allows for the exchange of proteins, lipids and
ions. Endoplasmic reticulum (ER) and mitochondria are physically linked and signal through …

10.7554/eLife.43561.001 The VPS13A gene is associated with the neurodegenerative disorder
Chorea Acanthocytosis. It is unknown what the consequences are of impaired function of …

Detection of neuronal cell death is a standard requirement in cell culture models of
neurodegenerative diseases. Although plenty of viability assays are available for in vitro …

Small conductance calcium-activated potassium (SK2/K Ca 2.2) channels are known to be
located in the neuronal plasma membrane where they provide feedback control of NMDA …

Polyglutamine expansion in the huntingtin protein is the primary genetic cause of Huntington’s
disease (HD). Fragments coinciding with mutant huntingtin exon1 aggregate in vivo and …