The capacities of urinary trefoil factor 3 (TFF3) and urinary albumin to detect acute renal
tubular injury have never been evaluated with sufficient statistical rigor to permit their use in …

In this study, approximately 40 endogenous metabolites were identified and quantified by 1
H NMR in urine samples from male rats dosed with two proximal tubule toxicants, cisplatin …

Drug-induced liver injury is a major reason for drug candidate attrition from development,
denied commercialization, market withdrawal, and restricted prescribing of pharmaceuticals. …

Transition metal ions are a challenge to study in physiology because of problems associated
with solubility, oxidation, binding, and attaining appropriate free activities in solution. This …

Mercuric ions are highly reactive and form a variety of organic complexes or conjugates in
vivo. The renal proximal tubule is a primary target for mercury uptake and toxicity, and …

… Using agglomerative hierarchical clustering with cosine similarity as a distance measure
across the entire 120-compound dataset, we confirmed that genes assigned to the same …

… As described previously by Aslamkhan et al 25 , 26 , these cells were transfected with the
cDNA for hOAT1 ligated to pcDNA3.1 (Invitrogen, Carlsbad, CA, USA) using Qiagen's (…

The natural sweetening agent stevioside and its aglycone metabolite, steviol, have been
shown to inhibit transepithelial transport of para-aminohippurate (PAH) in isolated rabbit renal …

… Aslamkhan *AG Aslamkhan and DM Thompson contributed equally to this work. … *AG
Aslamkhan and DM Thompson contributed equally to this work. …

Human hepatocellular carcinoma cells, HepG2, are often used for drug mediated mitochondrial
toxicity assessments. Glucose in HepG2 culture media is replaced by galactose to reveal …