Genome-wide expression analysis reveals dysregulation of myelination-related genes in chronic schizophrenia
…, V Haroutunian, AA Fienberg - Proceedings of the …, 2001 - National Acad Sciences
Neuropathological and brain imaging studies suggest that schizophrenia may result from
neurodevelopmental defects. Cytoarchitectural studies indicate cellular abnormalities …
neurodevelopmental defects. Cytoarchitectural studies indicate cellular abnormalities …
DARPP-32: regulator of the efficacy of dopaminergic neurotransmission
AA Fienberg, N Hiroi, PG Mermelstein, WJ Song… - Science, 1998 - science.org
Dopaminergic neurons exert a major modulatory effect on the forebrain. Dopamine and
adenosine 3′,5′-monophosphate–regulated phosphoprotein (32 kilodaltons) (DARPP-32), …
adenosine 3′,5′-monophosphate–regulated phosphoprotein (32 kilodaltons) (DARPP-32), …
Synapsins as mediators of BDNF-enhanced neurotransmitter release
JN Jovanovic, AJ Czernik, AA Fienberg… - Nature …, 2000 - nature.com
We examined enhancement of synaptic transmission by neurotrophins at the presynaptic
level. In a synaptosomal preparation, brain-derived neurotrophic factor (BDNF) increased …
level. In a synaptosomal preparation, brain-derived neurotrophic factor (BDNF) increased …
Phosphorylation of DARPP-32 by Cdk5 modulates dopamine signalling in neurons
The physiological state of the cell is controlled by signal transduction mechanisms which
regulate the balance between protein kinase and protein phosphatase activities 1 . Here we …
regulate the balance between protein kinase and protein phosphatase activities 1 . Here we …
Dopamine and cAMP-regulated phosphoprotein 32 kDa controls both striatal long-term depression and long-term potentiation, opposing forms of synaptic plasticity
…, K Chergui, P Svenningsson, AA Fienberg… - Journal of …, 2000 - Soc Neuroscience
A complex chain of intracellular signaling events, critically important in motor control, is
activated by the stimulation of D1-like dopamine (DA) receptors in striatal neurons. At …
activated by the stimulation of D1-like dopamine (DA) receptors in striatal neurons. At …
A dopamine/D1 receptor/protein kinase A/dopamine-and cAMP-regulated phosphoprotein (Mr 32 kDa)/protein phosphatase-1 pathway regulates dephosphorylation …
GL Snyder, AA Fienberg, RL Huganir… - Journal of …, 1998 - Soc Neuroscience
We have investigated the mechanism by which activation of dopamine (DA) receptors
regulates the glutamate sensitivity of medium spiny neurons of the nucleus accumbens. Our …
regulates the glutamate sensitivity of medium spiny neurons of the nucleus accumbens. Our …
Regulation of phosphorylation of the GluR1 AMPA receptor in the neostriatum by dopamine and psychostimulants in vivo
GL Snyder, PB Allen, AA Fienberg… - Journal of …, 2000 - Soc Neuroscience
The activation of cAMP-dependent protein kinase regulates the physiological activity of
AMPA-type glutamate receptors. In this study, phosphorylation of the AMPA receptor subunit …
AMPA-type glutamate receptors. In this study, phosphorylation of the AMPA receptor subunit …
Diverse psychotomimetics act through a common signaling pathway
…, S Wattler, M Nehls, DL McKinzie, AA Fienberg… - Science, 2003 - science.org
Three distinct classes of drugs: dopaminergic agonists (such as D-amphetamine),
serotonergic agonists (such as LSD), and glutamatergic antagonists (such as PCP) all induce …
serotonergic agonists (such as LSD), and glutamatergic antagonists (such as PCP) all induce …
Dopamine enhancement of NMDA currents in dissociated medium-sized striatal neurons: role of D1 receptors and DARPP-32
…, CR Calvert, ES Jokel, AA Fienberg… - Journal of …, 2002 - journals.physiology.org
Dopamine (DA), via activation of D1 receptors, enhancesN-methyl-d-aspartate (NMDA)-evoked
responses in striatal neurons. The present investigation examined further the properties …
responses in striatal neurons. The present investigation examined further the properties …
Protein phosphatase 1 modulation of neostriatal AMPA channels: Regulation by DARPP–32 and spinophilin
…, J Feng, K Tomizawa, PB Allen, AA Fienberg… - Nature …, 1999 - nature.com
Modulation of AMPA–type glutamate channels is important for synaptic plasticity. Here we
provide physiological evidence that the activity of AMPA channels is regulated by protein …
provide physiological evidence that the activity of AMPA channels is regulated by protein …