Precise coupling of spatially separated intracellular ATP-producing and ATP-consuming
processes is fundamental to the bioenergetics of living organisms, ensuring a fail-safe …

Adenylate kinase and downstream AMP signaling is an integrated metabolic monitoring
system which reads the cellular energy state in order to tune and report signals to metabolic …

The global impetus to identify curative therapies has been fuelled by the unmet needs of
patients in the context of a growing heart failure pandemic. To date, regeneration trials in …

The bioenergetics of somatic dedifferentiation into induced pluripotent stem cells remains
largely unknown. Here, stemness factor-mediated nuclear reprogramming reverted …

Atrial fibrillation is a rhythm disorder characterized by chaotic electrical activity of cardiac atria.
Predisposing to stroke and heart failure, this common condition is increasingly recognized …

Cardiogenesis within embryos or associated with heart repair requires stem cell differentiation
into energetically competent, contracting cardiomyocytes. While it is widely accepted that …

Background— Nuclear reprogramming provides an emerging strategy to produce embryo-independent
pluripotent stem cells from somatic tissue. Induced pluripotent stem cells (iPS) …

A crisis caused by COVID-19 pandemic affected the whole world leaving long-lasting effects
on almost every aspect of human lives. The aim of this study was to test how different effects …

Plasticity in energy metabolism allows stem cells to match the divergent demands of self-renewal
and lineage specification. Beyond a role in energetic support, new evidence implicates …

Stress tolerance of the heart requires high-fidelity metabolic sensing by ATP-sensitive
potassium (K ATP ) channels that adjust membrane potential–dependent functions to match …