Endorphin-mediated increases in pain threshold during pregnancy
AR Gintzler - Science, 1980 - science.org
Maternal pain thresholds in rats were determined during various stages of pregnancy and
parturition by measuring the intensity of electric shock that elicited reflexive jumping. There …
parturition by measuring the intensity of electric shock that elicited reflexive jumping. There …
Opioid tolerance and the emergence of new opioid receptor-coupled signaling
AR Gintzler, S Chakrabarti - Molecular neurobiology, 2000 - Springer
… In this article, Gintzler and Chakrabarti discuss the evidence that suggests that opioid
tolerance results not only from impaired opioid receptor functionality, but also from altered …
tolerance results not only from impaired opioid receptor functionality, but also from altered …
Formation of μ-/κ-opioid receptor heterodimer is sex-dependent and mediates female-specific opioid analgesia
…, NJ Liu, AR Gintzler - Proceedings of the …, 2010 - National Acad Sciences
Sexually dimorphic nociception and opioid antinociception is very pervasive but poorly
understood. We had demonstrated that spinal morphine antinociception in females, but not males…
understood. We had demonstrated that spinal morphine antinociception in females, but not males…
Importance of sex to pain and its amelioration; relevance of spinal estrogens and its membrane receptors
AR Gintzler, NJ Liu - Frontiers in neuroendocrinology, 2012 - Elsevier
Estrogens have a multitude of effects on opioid systems and are thought to play a key role in
sexually dimorphic nociception and opioid antinociception. Heretofore, classical genomic …
sexually dimorphic nociception and opioid antinociception. Heretofore, classical genomic …
Estrogen and progesterone activate spinal kappa-opiate receptor analgesic mechanisms
ME Dawson-Basoa, AR Gintzler - Pain, 1996 - journals.lww.com
: Rats and humans manifest elevated response thresholds to aversive stimuli during gestation
and parturition. This pregnancy-associated antinociception is mediated, in part, by a …
and parturition. This pregnancy-associated antinociception is mediated, in part, by a …
Post-opioid receptor adaptations to chronic morphine; altered functionality and associations of signaling molecules
AR Gintzler, S Chakrabarti - Life sciences, 2006 - Elsevier
Opioid desensitization/tolerance mechanisms have largely focused on adaptations that
occur on the level of the μ-opioid receptor (MOR) itself. These include opioid receptor …
occur on the level of the μ-opioid receptor (MOR) itself. These include opioid receptor …
Gestational and ovarian sex steroid antinociception: synergy between spinal κ and δ opioid systems
M Dawson-Basoa, AR Gintzler - Brain research, 1998 - Elsevier
Pain thresholds are elevated during gestation and following the simulation of pregnancy
blood levels of estrogen and progesterone (hormone simulated pregnancy; HSP). The …
blood levels of estrogen and progesterone (hormone simulated pregnancy; HSP). The …
17-β-estradiol and progesterone modulate an intrinsic opioid analgesic system
MB Dawson-Basoa, AR Gintzler - Brain research, 1993 - Elsevier
… 17 Sander, HW, Kream, RM and Gintzler, AR, Spinal dynorphin involvement in the analgesia
of pregnancy: effects of intrathecal dynorphin antisera, Eur. J. Pharmacol., 159 (1989) 205-…
of pregnancy: effects of intrathecal dynorphin antisera, Eur. J. Pharmacol., 159 (1989) 205-…
Spinal synthesis of estrogen and concomitant signaling by membrane estrogen receptors regulate spinal κ-and μ-opioid receptor heterodimerization and female …
…, S Schnell, M Wessendorf, AR Gintzler - Journal of …, 2011 - Soc Neuroscience
We previously demonstrated that the spinal cord κ-opioid receptor (KOR) and μ-opioid
receptor (MOR) form heterodimers (KOR/MOR). KOR/MOR formation and the associated KOR …
receptor (MOR) form heterodimers (KOR/MOR). KOR/MOR formation and the associated KOR …
Prolonged ovarian sex steroid treatment of male rats produces antinociception: identification of sex-based divergent analgesic mechanisms
NJ Liu, AR Gintzler - Pain, 2000 - Elsevier
Simulation of the pregnancy blood concentration profile of 17β-estradiol (E 2 ) and
progesterone (P) in nonpregnant ovariectomized rats has been shown to result in a significant …
progesterone (P) in nonpregnant ovariectomized rats has been shown to result in a significant …