Explaining the phenomenon of nitrate tolerance

T Münzel, A Daiber, A Mülsch - Circulation research, 2005 - Am Heart Assoc
During the last century, nitroglycerin has been the most commonly used antiischemic and
antianginal agent. Unfortunately, after continuous application, its therapeutic efficacy rapidly …

Vascular consequences of endothelial nitric oxide synthase uncoupling for the activity and expression of the soluble guanylyl cyclase and the cGMP-dependent …

T Münzel, A Daiber, V Ullrich… - … thrombosis, and vascular …, 2005 - Am Heart Assoc
Endothelial dysfunction in the setting of cardiovascular risk factors, such as hypercholesterolemia,
hypertension, diabetes mellitus, chronic smoking, as well as in the setting of heart …

Physiology and pathophysiology of vascular signaling controlled by cyclic guanosine 3′, 5′-cyclic monophosphate–dependent protein kinase

T Münzel, R Feil, A Mülsch, SM Lohmann… - Circulation, 2003 - Am Heart Assoc
defects, desensitization, or other aberrations in the pathways distal to NO/NPs must be
recognized as capable of derailing the desired procession of events. The ensuing discussion …

[HTML][HTML] Nitric oxide inhibits caspase-3 by S-nitrosationin vivo

…, J Haendeler, AM Zeiher, A Mulsch… - Journal of Biological …, 1999 - ASBMB
In cultured human endothelial cells, physiological levels of NO prevent apoptosis and
interfere with the activation of the caspase cascade. In vitro data have demonstrated that NO …

[HTML][HTML] Central role of mitochondrial aldehyde dehydrogenase and reactive oxygen species in nitroglycerin tolerance and cross-tolerance

…, M Wendt, V Ullrich, A Mülsch… - The Journal of …, 2004 - Am Soc Clin Investig
Recent studies suggest that mitochondrial aldehyde dehydrogenase (ALDH-2) plays a central
role in the process of nitroglycerin (glyceryl trinitrate, GTN) biotransformation in vivo and …

[HTML][HTML] S-nitrosation of serum albumin by dinitrosyl-iron complex

…, PI Mordvintcev, AF Vanin, R Busse, A Mülsch - Journal of Biological …, 1995 - ASBMB
The objective of this study was to identify a potential mechanism for S-nitrosation of proteins.
Therefore, we assessed S-nitrosation of bovine serum albumin by dinitrosyl-iron-di-L-…

Effect of YC‐1, an NO‐independent, superoxide‐sensitive stimulator of soluble guanylyl cyclase, on smooth muscle responsiveness to nitrovasodilators

A Mülsch, J Bauersachs, A Schäfer… - British journal of …, 1997 - Wiley Online Library
1 We studied the effects of 3‐(5′‐hydroxymethyl‐2′furyl)‐1‐benzyl indazole (YC‐1) on
the activity of purified soluble guanylyl cyclase (sGC), the formation of guanosine‐3′: 5′…

Nebivolol inhibits superoxide formation by NADPH oxidase and endothelial dysfunction in angiotensin II–treated rats

M Oelze, A Daiber, RP Brandes, M Hortmann… - …, 2006 - Am Heart Assoc
Nebivolol is a β 1 -receptor antagonist with vasodilator and antioxidant properties. Because
the vascular NADPH oxidase is an important superoxide source, we studied the effect of …

Mitochondrial dysfunction, peroxidation damage and changes in glutathione metabolism in PARK6

…, B Morales, O Wingerter, D Del Turco, A Mülsch… - Neurobiology of …, 2007 - Elsevier
Oxidative stress and protein aggregation are biochemical hallmarks of Parkinson’s disease (PD),
a frequent sporadic late-onset degenerative disorder particularly of dopaminergic …

Does nitric oxide mediate the vasodilator activity of nitroglycerin?

AL Kleschyov, M Oelze, A Daiber, Y Huang… - Circulation …, 2003 - Am Heart Assoc
Nitroglycerin (glyceryl trinitrate, GTN) relaxes blood vessels primarily via activation of the
soluble guanylyl cyclase (sGC)/cGMP/cGMP-dependent protein kinase (cGK-I) pathway. …