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16648370,17486662,18499100,16050953,20546737,18078308,17369525,17482289,16731832,17065392,19217455,17292977,17054919,17630003,16682937,16979397,21304061,15749809,16859646,17263764,18200618,12524666,22281473,16730098,18085721,21332446,11111014,18034839,15101559,17983555,18499057,20540938,19865180,16675042,19038243,22015634,22665137,19531053,23891763,12242459,19497359,23618969,15039452,21205124,16731793,9117102,18835930,16027230,18090226,16050949,11699060,16523410,16980568,15212985,24684824,18819058,18466898,20005261,16979408,17087662,16259883,19208898,23092878,23897163,15715890,3525360,22862961,22587909,21371430,24406898,17184947,19698772,28619366,25060150,23784442,31539596,22867941,12808880,16945366,14719796,23085436,27062006,20804731,18977255,32320703,25929155,21345512,16380499,20415690,21904107,15803906,21549160,16403774,16389169,24902584,25337656,28408435,21747318,15654653,15930172,20590744,10969840,15826475,22820565,15563754,7028589,19647775,24858371,17573070,21471191,29412820,15845923,21093089,25256010,22948814,30041175,8839256,21756932,26234524,20592721,14759771,17267075,21824266,23138973,28424924,23590680,21811909,26208278,27068334,16207089,9533568,25301258,19706786,16378704,3549500,19836346,20158440,19748063,26481165,1966872,12136396,23117087,25938469,22960403,22695119,19798700,29992313,16150917,34054734,29524296,11980629,16280413,16046312,16586064,20939591,14985056,3899464,22356440,12606517,20735990,14630571,34781035,31102890,29777582,20920042,20112724,30728346,16551338,23877319,20546289,33677993,3543585,19515180,33588009,17267112,21595282,20196040,25720341,29759973,25962313,25115772,10024091,12217892,19781890,20720576,22799463,25527001,21550078,20561948,21621561,18201212,30028989,19766107,28626167,3905189,26963143,21419173,23790528,15694706,7043679,29540315,28717164,7040198,11517452,16049395,26351642,23410183,22911568,21872612,20599702,10331407,16112402,12975499,14742740,24094437,20417187,1675542,22889326,18511515,19654434,21255808,32413586,22830490,21312223,22118536,27377054,26095087,20498254,18412318,25970118,22421983,15173883,19615995,22842733,27357054,18704955,16179267,21381002,9329975,1183915,23658425,12180885,3767527,24289070,11511090,23055535,11972300,24771009,15044053,23348707,25051441,2124625,25940922,25792018,27540823,15923344,29412816,26040899,29412822,6354790,26789107,31669388,22936676,8200619,26349938,18191122,22986487,21396168,15655712,11495687,28750064,23839539,23562625,23632200,15016242,18695644,16316644,25967277,29525225,23746147,11855690,28801559,23834832,10933882,19821955,21294225,16406202,29351476,31182471,26178446,23827952,18326786,25825945,21750265,16115378,26239054,29409356,15852457,24962667,17164779,33258802,9918555,23488782,2572664,24985367,28211608,28746825,16382307,25984632,18819251,27677765,33482185,27965024,22530993,26138324,29763559,17299087,25022210,29545266,28730728,22176969,22822165,10602340,30499633,21664938,12230007,16132949,16987706,30225696,26417688,22249815,10828847,23238530,31451647,8033197,22790061,12031973,17970756,24398402,23149623,26505796,23353893,11324423,24836562,26512980,21495117,21114600,35718129,32739864,19732123,26123844,22342354,21952036,10910007,369939,21756875,23769065,23720456,8699817,21347622,23707756,15816415,24397172,26537124,33309687,26744903,26683792,20151999,24085036,33252358,29349894,347739,32477262,29601817,12231394,26802310,29549522,16443769,30541952,9392491,3038765,18804128,19884767,3082567,25813215,16929351,19702274,24386218,15247183,19897925,24510483,18579346,12967942,25633666,27150301,31693486,25463759,12552113,17142143,20616206,26020795,26808305,21094907,21216666,1594559,27167773,27232339,21115020,21836527,21114599,16857751,21600946,16439839,21295809,3278192,30396073,30830262,25533471,29057588,12529490,27160799,30301245,17575548,15140593,29673717,24709081,27068377,32339440,20856794,31404283,16142810,21075654,28629388,27610615,20531351,17632702,22506938,22268426,26895657,23274897,21205126,20623590,23118741,28342399,6386585,21211384,25401335,17268057,16526046,25230237,3071470,15070170,32473615,26802468,28152036,17764693,9544208,1248793,1976559,28659588,18757549,29355505,24462047,30520247,27780713,24372241,23743192,17311896,33078809,11112365,29556780,33839290,15080500,28461341,33977593,12644390,25973898,29327400,24712877,25812369,27081750,34547355,10952686,6320237,25459513,9645685,30031858,26308095,15024641,12940869,9781841,23751906,25148830,24236842,30860869,9927305,25757909,131728,24379349,17986790,30404557,25563725,10479309,365655,29504946,1707061,10868966,28108376,26551045,21307364,18359095,29401602,26406478,30462197,24373324,20950599,21638778,20149450,20734435,30721719,20032055,22284602,16892141,26384018,2067974,2776470,20841608,37001706,25724479,28948559,14617225,16516154,30305366,25374384,28193789,24804243,24674587,34717897,22297305,36006576,15949698,28771355,17003351,26699764,7040265,25483926,28947828,34450223,20217510,19041364,6757362,24690390,8876750,21595267,2576006,1994379,28181829,3325700,15374756,15982784,29155303,33453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758 results

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Novel glucagon-like peptide-1 (GLP-1) analog (Val8)GLP-1 results in significant improvements of glucose tolerance and pancreatic beta-cell function after 3-week daily administration in obese diabetic (ob/ob) mice.

Green BD, Lavery KS, Irwin N, O'harte FP, Harriott P, Greer B, Bailey CJ, Flatt PR. Green BD, et al. J Pharmacol Exp Ther. 2006 Aug;318(2):914-21. doi: 10.1124/jpet.105.097824. Epub 2006 Apr 28. J Pharmacol Exp Ther. 2006. PMID: 16648370

Comparison of the subchronic antidiabetic effects of DPP IV-resistant GIP and GLP-1 analogues in obese diabetic (ob/ob) mice.

Irwin N, McClean PL, Flatt PR. Irwin N, et al. J Pept Sci. 2007 Jun;13(6):400-5. doi: 10.1002/psc.861. J Pept Sci. 2007. PMID: 17486662

Chronic administration of alogliptin, a novel, potent, and highly selective dipeptidyl peptidase-4 inhibitor, improves glycemic control and beta-cell function in obese diabetic ob/ob mice.

Moritoh Y, Takeuchi K, Asakawa T, Kataoka O, Odaka H. Moritoh Y, et al. Eur J Pharmacol. 2008 Jul 7;588(2-3):325-32. doi: 10.1016/j.ejphar.2008.04.018. Epub 2008 Apr 10. Eur J Pharmacol. 2008. PMID: 18499100

A comparison of the cellular and biological properties of DPP-IV-resistant N-glucitol analogues of glucagon-like peptide-1 and glucose-dependent insulinotropic polypeptide.

Green BD, Gault VA, O'Harte FP, Flatt PR. Green BD, et al. Diabetes Obes Metab. 2005 Sep;7(5):595-604. doi: 10.1111/j.1463-1326.2004.00455.x. Diabetes Obes Metab. 2005. PMID: 16050953

Glucagon-like peptide-2 receptor modulates islet adaptation to metabolic stress in the ob/ob mouse.

Bahrami J, Longuet C, Baggio LL, Li K, Drucker DJ. Bahrami J, et al. Gastroenterology. 2010 Sep;139(3):857-68. doi: 10.1053/j.gastro.2010.05.006. Epub 2010 Jun 11. Gastroenterology. 2010. PMID: 20546737

Preparation, characterization, and application of biotinylated and biotin-PEGylated glucagon-like peptide-1 analogues for enhanced oral delivery.

Chae SY, Jin CH, Shin HJ, Youn YS, Lee S, Lee KC. Chae SY, et al. Bioconjug Chem. 2008 Jan;19(1):334-41. doi: 10.1021/bc700292v. Epub 2007 Dec 14. Bioconjug Chem. 2008. PMID: 18078308

Glucagon-like peptide-1 gene therapy in obese diabetic mice results in long-term cure of diabetes by improving insulin sensitivity and reducing hepatic gluconeogenesis.

Lee YS, Shin S, Shigihara T, Hahm E, Liu MJ, Han J, Yoon JW, Jun HS. Lee YS, et al. Diabetes. 2007 Jun;56(6):1671-9. doi: 10.2337/db06-1182. Epub 2007 Mar 16. Diabetes. 2007. PMID: 17369525

DPP-4 inhibition improves glucose tolerance and increases insulin and GLP-1 responses to gastric glucose in association with normalized islet topography in mice with beta-cell-specific overexpression of human islet amyloid polypeptide.

Ahrén B, Winzell MS, Wierup N, Sundler F, Burkey B, Hughes TE. Ahrén B, et al. Regul Pept. 2007 Oct 4;143(1-3):97-103. doi: 10.1016/j.regpep.2007.03.008. Epub 2007 Apr 11. Regul Pept. 2007. PMID: 17482289

Chronic inhibition of dipeptidyl peptidase-4 with a sitagliptin analog preserves pancreatic beta-cell mass and function in a rodent model of type 2 diabetes.

Mu J, Woods J, Zhou YP, Roy RS, Li Z, Zycband E, Feng Y, Zhu L, Li C, Howard AD, Moller DE, Thornberry NA, Zhang BB. Mu J, et al. Diabetes. 2006 Jun;55(6):1695-704. doi: 10.2337/db05-1602. Diabetes. 2006. PMID: 16731832

Effects of sub-chronic exposure to naturally occurring N-terminally truncated metabolites of glucose-dependent insulinotrophic polypeptide (GIP) and glucagon-like peptide-1 (GLP-1), GIP(3-42) and GLP-1(9-36)amide, on insulin secretion and glucose homeostasis in ob/ob mice.

Parker JC, Lavery KS, Irwin N, Green BD, Greer B, Harriott P, O'Harte FP, Gault VA, Flatt PR. Parker JC, et al. J Endocrinol. 2006 Oct;191(1):93-100. doi: 10.1677/joe.1.06904. J Endocrinol. 2006. PMID: 17065392

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