Similar articles for PMID: 16040814

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1988	1
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1

Fenobam: a clinically validated nonbenzodiazepine anxiolytic is a potent, selective, and noncompetitive mGlu5 receptor antagonist with inverse agonist activity.

Porter RH, Jaeschke G, Spooren W, Ballard TM, Büttelmann B, Kolczewski S, Peters JU, Prinssen E, Wichmann J, Vieira E, Mühlemann A, Gatti S, Mutel V, Malherbe P. Porter RH, et al. J Pharmacol Exp Ther. 2005 Nov;315(2):711-21. doi: 10.1124/jpet.105.089839. Epub 2005 Jul 22. J Pharmacol Exp Ther. 2005. PMID: 16040814

2

CTEP: a novel, potent, long-acting, and orally bioavailable metabotropic glutamate receptor 5 inhibitor.

Lindemann L, Jaeschke G, Michalon A, Vieira E, Honer M, Spooren W, Porter R, Hartung T, Kolczewski S, Büttelmann B, Flament C, Diener C, Fischer C, Gatti S, Prinssen EP, Parrott N, Hoffmann G, Wettstein JG. Lindemann L, et al. J Pharmacol Exp Ther. 2011 Nov;339(2):474-86. doi: 10.1124/jpet.111.185660. Epub 2011 Aug 17. J Pharmacol Exp Ther. 2011. PMID: 21849627

3

Comparison of the binding pockets of two chemically unrelated allosteric antagonists of the mGlu5 receptor and identification of crucial residues involved in the inverse agonism of MPEP.

Malherbe P, Kratochwil N, Mühlemann A, Zenner MT, Fischer C, Stahl M, Gerber PR, Jaeschke G, Porter RH. Malherbe P, et al. J Neurochem. 2006 Jul;98(2):601-15. doi: 10.1111/j.1471-4159.2006.03886.x. J Neurochem. 2006. PMID: 16805850 Free article.

4

The metabotropic glutamate receptor subtype 5 antagonist fenobam is analgesic and has improved in vivo selectivity compared with the prototypical antagonist 2-methyl-6-(phenylethynyl)-pyridine.

Montana MC, Cavallone LF, Stubbert KK, Stefanescu AD, Kharasch ED, Gereau RW 4th. Montana MC, et al. J Pharmacol Exp Ther. 2009 Sep;330(3):834-43. doi: 10.1124/jpet.109.154138. Epub 2009 Jun 10. J Pharmacol Exp Ther. 2009. PMID: 19515968 Free PMC article.

5

The anxiolytic and analgesic properties of fenobam, a potent mGlu5 receptor antagonist, in relation to the impairment of learning.

Jacob W, Gravius A, Pietraszek M, Nagel J, Belozertseva I, Shekunova E, Malyshkin A, Greco S, Barberi C, Danysz W. Jacob W, et al. Neuropharmacology. 2009 Aug;57(2):97-108. doi: 10.1016/j.neuropharm.2009.04.011. Epub 2009 May 6. Neuropharmacology. 2009. PMID: 19426746

6

Potential anxiolytic- and antidepressant-like effects of MPEP, a potent, selective and systemically active mGlu5 receptor antagonist.

Tatarczyńska E, Klodzińska A, Chojnacka-Wójcik E, Palucha A, Gasparini F, Kuhn R, Pilc A. Tatarczyńska E, et al. Br J Pharmacol. 2001 Apr;132(7):1423-30. doi: 10.1038/sj.bjp.0703923. Br J Pharmacol. 2001. PMID: 11264235 Free PMC article.

7

Anxiolytic-like effects of group I metabotropic glutamate antagonist 2-methyl-6-(phenylethynyl)-pyridine (MPEP) in rats.

Kłodzińska A, Tatarczyńska E, Chojnacka-Wójcik E, Pilc A. Kłodzińska A, et al. Pol J Pharmacol. 2000 Nov-Dec;52(6):463-6. Pol J Pharmacol. 2000. PMID: 11334240

8

The behavioral profile of the potent and selective mGlu5 receptor antagonist 3-[(2-methyl-1,3-thiazol-4-yl)ethynyl]pyridine (MTEP) in rodent models of anxiety.

Busse CS, Brodkin J, Tattersall D, Anderson JJ, Warren N, Tehrani L, Bristow LJ, Varney MA, Cosford ND. Busse CS, et al. Neuropsychopharmacology. 2004 Nov;29(11):1971-9. doi: 10.1038/sj.npp.1300540. Neuropsychopharmacology. 2004. PMID: 15305166

9

Anxiolytic-like effects of mGlu1 and mGlu5 receptor antagonists in rats.

Pietraszek M, Sukhanov I, Maciejak P, Szyndler J, Gravius A, Wisłowska A, Płaźnik A, Bespalov AY, Danysz W. Pietraszek M, et al. Eur J Pharmacol. 2005 May 2;514(1):25-34. doi: 10.1016/j.ejphar.2005.03.028. Epub 2005 Apr 19. Eur J Pharmacol. 2005. PMID: 15878321

10

The effect of the mGlu5 receptor antagonist MPEP in rodent tests of anxiety and cognition: a comparison.

Ballard TM, Woolley ML, Prinssen E, Huwyler J, Porter R, Spooren W. Ballard TM, et al. Psychopharmacology (Berl). 2005 Apr;179(1):218-29. doi: 10.1007/s00213-005-2211-9. Epub 2005 Mar 1. Psychopharmacology (Berl). 2005. PMID: 15739074

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