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Page 1
Discovery of (3-(4-(2-Oxa-6-azaspiro[3.3]heptan-6-ylmethyl)phenoxy)azetidin-1-yl)(5-(4-methoxyphenyl)-1,3,4-oxadiazol-2-yl)methanone (AZD1979), a Melanin Concentrating Hormone Receptor 1 (MCHr1) Antagonist with Favorable Physicochemical Properties.
J Med Chem. 2016 Mar 24;59(6):2497-511. doi: 10.1021/acs.jmedchem.5b01654. Epub 2016 Feb 5.
J Med Chem. 2016.
PMID: 26741166
Synthesis and pharmacological evaluation of novel gamma-aminobutyric acid type B (GABAB) receptor agonists as gastroesophageal reflux inhibitors.
Alstermark C, Amin K, Dinn SR, Elebring T, Fjellström O, Fitzpatrick K, Geiss WB, Gottfries J, Guzzo PR, Harding JP, Holmén A, Kothare M, Lehmann A, Mattsson JP, Nilsson K, Sundén G, Swanson M, von Unge S, Woo AM, Wyle MJ, Zheng X.
Alstermark C, et al. Among authors: von unge s.
J Med Chem. 2008 Jul 24;51(14):4315-20. doi: 10.1021/jm701425k. Epub 2008 Jun 25.
J Med Chem. 2008.
PMID: 18578471
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Different in vitro and in vivo profiles of substituted 3-aminopropylphosphinate and 3-aminopropyl(methyl)phosphinate GABA(B) receptor agonists as inhibitors of transient lower oesophageal sphincter relaxation.
Lehmann A, Antonsson M, Aurell-Holmberg A, Blackshaw LA, Brändén L, Elebring T, Jensen J, Kärrberg L, Mattsson JP, Nilsson K, Oja SS, Saransaari P, von Unge S.
Lehmann A, et al. Among authors: von unge s.
Br J Pharmacol. 2012 Mar;165(6):1757-1772. doi: 10.1111/j.1476-5381.2011.01682.x.
Br J Pharmacol. 2012.
PMID: 21950457
Free PMC article.
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(R)-(3-amino-2-fluoropropyl) phosphinic acid (AZD3355), a novel GABAB receptor agonist, inhibits transient lower esophageal sphincter relaxation through a peripheral mode of action.
Lehmann A, Antonsson M, Holmberg AA, Blackshaw LA, Brändén L, Bräuner-Osborne H, Christiansen B, Dent J, Elebring T, Jacobson BM, Jensen J, Mattsson JP, Nilsson K, Oja SS, Page AJ, Saransaari P, von Unge S.
Lehmann A, et al. Among authors: von unge s.
J Pharmacol Exp Ther. 2009 Nov;331(2):504-12. doi: 10.1124/jpet.109.153593. Epub 2009 Jul 31.
J Pharmacol Exp Ther. 2009.
PMID: 19648470
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13C assignments of the carbon atoms in the aromatic rings of lignin model compounds of the arylglycerol beta-aryl ether type.
Bardet M, Lundquist K, Parkås J, Robert D, von Unge S.
Bardet M, et al. Among authors: von unge s.
Magn Reson Chem. 2006 Oct;44(10):976-9. doi: 10.1002/mrc.1877.
Magn Reson Chem. 2006.
PMID: 16835899
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