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Year Number of Results
2003 3
2004 2
2005 1
2014 3
2015 2
2024 0

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Page 1
Dibenzazepines and dibenzoxazepines as sodium channel blockers.
Lynch SM, Tafesse L, Carlin K, Ghatak P, Kyle DJ. Lynch SM, et al. Among authors: tafesse l. Bioorg Med Chem Lett. 2015 Jan 1;25(1):43-7. doi: 10.1016/j.bmcl.2014.11.025. Epub 2014 Nov 14. Bioorg Med Chem Lett. 2015. PMID: 25466191
N-Aryl azacycles as novel sodium channel blockers.
Lynch SM, Tafesse L, Carlin K, Ghatak P, Shao B, Abdelhamid H, Kyle DJ. Lynch SM, et al. Among authors: tafesse l. Bioorg Med Chem Lett. 2015 Jan 1;25(1):48-52. doi: 10.1016/j.bmcl.2014.11.023. Epub 2014 Nov 14. Bioorg Med Chem Lett. 2015. PMID: 25435147
Structure-activity relationship studies and discovery of a potent transient receptor potential vanilloid (TRPV1) antagonist 4-[3-chloro-5-[(1S)-1,2-dihydroxyethyl]-2-pyridyl]-N-[5-(trifluoromethyl)-2-pyridyl]-3,6-dihydro-2H-pyridine-1-carboxamide (V116517) as a clinical candidate for pain management.
Tafesse L, Kanemasa T, Kurose N, Yu J, Asaki T, Wu G, Iwamoto Y, Yamaguchi Y, Ni C, Engel J, Tsuno N, Patel A, Zhou X, Shintani T, Brown K, Hasegawa T, Shet M, Iso Y, Kato A, Kyle DJ. Tafesse L, et al. J Med Chem. 2014 Aug 14;57(15):6781-94. doi: 10.1021/jm500818a. Epub 2014 Aug 1. J Med Chem. 2014. PMID: 25057800
Pharmacological and pharmacokinetic characterization of the cannabinoid receptor 2 agonist, GW405833, utilizing rodent models of acute and chronic pain, anxiety, ataxia and catalepsy.
Valenzano KJ, Tafesse L, Lee G, Harrison JE, Boulet JM, Gottshall SL, Mark L, Pearson MS, Miller W, Shan S, Rabadi L, Rotshteyn Y, Chaffer SM, Turchin PI, Elsemore DA, Toth M, Koetzner L, Whiteside GT. Valenzano KJ, et al. Among authors: tafesse l. Neuropharmacology. 2005 Apr;48(5):658-72. doi: 10.1016/j.neuropharm.2004.12.008. Neuropharmacology. 2005. PMID: 15814101
N-(4-tertiarybutylphenyl)-4-(3-chloropyridin-2-yl)tetrahydropyrazine -1(2H)-carbox-amide (BCTC), a novel, orally effective vanilloid receptor 1 antagonist with analgesic properties: I. in vitro characterization and pharmacokinetic properties.
Valenzano KJ, Grant ER, Wu G, Hachicha M, Schmid L, Tafesse L, Sun Q, Rotshteyn Y, Francis J, Limberis J, Malik S, Whittemore ER, Hodges D. Valenzano KJ, et al. Among authors: tafesse l. J Pharmacol Exp Ther. 2003 Jul;306(1):377-86. doi: 10.1124/jpet.102.045674. Epub 2003 Apr 29. J Pharmacol Exp Ther. 2003. PMID: 12721338
4-(2-pyridyl)piperazine-1-carboxamides: potent vanilloid receptor 1 antagonists.
Sun Q, Tafesse L, Islam K, Zhou X, Victory SF, Zhang C, Hachicha M, Schmid LA, Patel A, Rotshteyn Y, Valenzano KJ, Kyle DJ. Sun Q, et al. Among authors: tafesse l. Bioorg Med Chem Lett. 2003 Oct 20;13(20):3611-6. doi: 10.1016/s0960-894x(03)00759-5. Bioorg Med Chem Lett. 2003. PMID: 14505681