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1999 1
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2011 3
2012 1
2021 1
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12 results

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Page 1
DCAF11 Supports Targeted Protein Degradation by Electrophilic Proteolysis-Targeting Chimeras.
Zhang X, Luukkonen LM, Eissler CL, Crowley VM, Yamashita Y, Schafroth MA, Kikuchi S, Weinstein DS, Symons KT, Nordin BE, Rodriguez JL, Wucherpfennig TG, Bauer LG, Dix MM, Stamos D, Kinsella TM, Simon GM, Baltgalvis KA, Cravatt BF. Zhang X, et al. Among authors: symons kt. J Am Chem Soc. 2021 Apr 7;143(13):5141-5149. doi: 10.1021/jacs.1c00990. Epub 2021 Mar 30. J Am Chem Soc. 2021. PMID: 33783207 Free PMC article.
Alpha-mercaptoketone based histone deacetylase inhibitors.
Wash PL, Hoffman TZ, Wiley BM, Bonnefous C, Smith ND, Sertic MS, Lawrence CM, Symons KT, Nguyen PM, Lustig KD, Guo X, Annable T, Noble SA, Hager JH, Hassig CA, Malecha JW. Wash PL, et al. Among authors: symons kt. Bioorg Med Chem Lett. 2008 Dec 15;18(24):6482-5. doi: 10.1016/j.bmcl.2008.10.058. Epub 2008 Oct 17. Bioorg Med Chem Lett. 2008. PMID: 18954984
Heteroaromatic-aminomethyl quinolones: potent and selective iNOS inhibitors.
Durón SG, Lindstrom A, Bonnefous C, Zhang H, Chen X, Symons KT, Sablad M, Rozenkrants N, Zhang Y, Wang L, Yazdani N, Shiau AK, Noble SA, Rix P, Rao TS, Hassig CA, Smith ND. Durón SG, et al. Among authors: symons kt. Bioorg Med Chem Lett. 2012 Jan 15;22(2):1237-41. doi: 10.1016/j.bmcl.2011.11.073. Epub 2011 Nov 25. Bioorg Med Chem Lett. 2012. PMID: 22182498
Identification of KD5170: a novel mercaptoketone-based histone deacetylase inhibitor.
Payne JE, Bonnefous C, Hassig CA, Symons KT, Guo X, Nguyen PM, Annable T, Wash PL, Hoffman TZ, Rao TS, Shiau AK, Malecha JW, Noble SA, Hager JH, Smith ND. Payne JE, et al. Among authors: symons kt. Bioorg Med Chem Lett. 2008 Dec 1;18(23):6093-6. doi: 10.1016/j.bmcl.2008.10.029. Epub 2008 Oct 11. Bioorg Med Chem Lett. 2008. PMID: 18954983
Pharmacological characterization of KLYP961, a dual inhibitor of inducible and neuronal nitric-oxide synthases.
Symons KT, Nguyen PM, Massari ME, Anzola JV, Staszewski LM, Wang L, Yazdani N, Dorow S, Muhammad J, Sablad M, Rozenkrants N, Bonefous C, Payne JE, Rix PJ, Shiau AK, Noble SA, Smith ND, Hassig CA, Zhang Y, Rao TS. Symons KT, et al. J Pharmacol Exp Ther. 2011 Feb;336(2):468-78. doi: 10.1124/jpet.110.172817. Epub 2010 Oct 29. J Pharmacol Exp Ther. 2011. PMID: 21036913
Discovery of dual inducible/neuronal nitric oxide synthase (iNOS/nNOS) inhibitor development candidate 4-((2-cyclobutyl-1H-imidazo[4,5-b]pyrazin-1-yl)methyl)-7,8-difluoroquinolin-2(1H)-one (KD7332) part 2: identification of a novel, potent, and selective series of benzimidazole-quinolinone iNOS/nNOS dimerization inhibitors that are orally active in pain models.
Payne JE, Bonnefous C, Symons KT, Nguyen PM, Sablad M, Rozenkrants N, Zhang Y, Wang L, Yazdani N, Shiau AK, Noble SA, Rix P, Rao TS, Hassig CA, Smith ND. Payne JE, et al. Among authors: symons kt. J Med Chem. 2010 Nov 11;53(21):7739-55. doi: 10.1021/jm100828n. J Med Chem. 2010. PMID: 20931971
Discovery of inducible nitric oxide synthase (iNOS) inhibitor development candidate KD7332, part 1: Identification of a novel, potent, and selective series of quinolinone iNOS dimerization inhibitors that are orally active in rodent pain models.
Bonnefous C, Payne JE, Roppe J, Zhuang H, Chen X, Symons KT, Nguyen PM, Sablad M, Rozenkrants N, Zhang Y, Wang L, Severance D, Walsh JP, Yazdani N, Shiau AK, Noble SA, Rix P, Rao TS, Hassig CA, Smith ND. Bonnefous C, et al. Among authors: symons kt. J Med Chem. 2009 May 14;52(9):3047-62. doi: 10.1021/jm900173b. J Med Chem. 2009. PMID: 19374401
12 results