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Page 1
Rational drug design and synthesis of a highly selective nonpeptide delta-opioid agonist, (4aS*,12aR*)-4a-(3-hydroxyphenyl)-2-methyl- 1,2,3,4,4a,5,12,12a-octahydropyrido[3,4-b]acridine (TAN-67).
Chem Pharm Bull (Tokyo). 1998 Nov;46(11):1695-702. doi: 10.1248/cpb.46.1695.
Chem Pharm Bull (Tokyo). 1998.
PMID: 9845952
Supraspinal delta 1-opioid receptor-mediated antinociceptive properties of (-)-TAN-67 in diabetic mice.
Kamei J, Kawai K, Mizusuna A, Saitoh A, Morita K, Narita M, Tseng LF, Nagase H.
Kamei J, et al. Among authors: mizusuna a.
Eur J Pharmacol. 1997 Mar 12;322(1):27-30. doi: 10.1016/s0014-2999(97)00085-x.
Eur J Pharmacol. 1997.
PMID: 9088866
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Delta-1 opioid receptor-mediated antinociceptive properties of a nonpeptidic delta opioid receptor agonist, (-)TAN-67, in the mouse spinal cord.
Tseng LF, Narita M, Mizoguchi H, Kawai K, Mizusuna A, Kamei J, Suzuki T, Nagase H.
Tseng LF, et al. Among authors: mizusuna a.
J Pharmacol Exp Ther. 1997 Feb;280(2):600-5.
J Pharmacol Exp Ther. 1997.
PMID: 9023269
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Synthesis of optically active TAN-67, a highly selective delta opioid receptor agonist, and investigation of its pharmacological properties.
Fujii H, Kawai K, Kawamura K, Mizusuna A, Onoda Y, Murachi M, Tanaka T, Endoh T, Nagase H.
Fujii H, et al. Among authors: mizusuna a.
Drug Des Discov. 2001;17(4):325-30.
Drug Des Discov. 2001.
PMID: 11765135
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