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DAT/SERT selectivity of flexible GBR 12909 analogs modeled using 3D-QSAR methods.
Gilbert KM, Boos TL, Dersch CM, Greiner E, Jacobson AE, Lewis D, Matecka D, Prisinzano TE, Zhang Y, Rothman RB, Rice KC, Venanzi CA. Gilbert KM, et al. Among authors: matecka d. Bioorg Med Chem. 2007 Jan 15;15(2):1146-59. doi: 10.1016/j.bmc.2006.09.070. Epub 2006 Oct 1. Bioorg Med Chem. 2007. PMID: 17127069 Free PMC article.
Development of novel, potent, and selective dopamine reuptake inhibitors through alteration of the piperazine ring of 1-[2-(diphenylmethoxy)ethyl]-and 1-[2-[bis(4-fluorophenyl)methoxy]ethyl]-4-(3-phenylpropyl)piperazines (GBR 12935 and GBR 12909).
Matecka D, Rothman RB, Radesca L, de Costa BR, Dersch CM, Partilla JS, Pert A, Glowa JR, Wojnicki FH, Rice KC. Matecka D, et al. J Med Chem. 1996 Nov 22;39(24):4704-16. doi: 10.1021/jm960305h. J Med Chem. 1996. PMID: 8941383
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