Selective estrogen receptor-beta (SERM-beta) compounds modulate raphe nuclei tryptophan hydroxylase-1 (TPH-1) mRNA expression and cause antidepressant-like effects in the forced swim test.
Clark JA, Alves S, Gundlah C, Rocha B, Birzin ET, Cai SJ, Flick R, Hayes E, Ho K, Warrier S, Pai L, Yudkovitz J, Fleischer R, Colwell L, Li S, Wilkinson H, Schaeffer J, Wilkening R, Mattingly E, Hammond M, Rohrer SP.
Clark JA, et al. Among authors: gundlah c.
Neuropharmacology. 2012 Nov;63(6):1051-63. doi: 10.1016/j.neuropharm.2012.07.004. Epub 2012 Jul 13.
Neuropharmacology. 2012.
PMID: 22796107