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Year Number of Results
2008 1
2009 1
2010 1
2012 4
2013 5
2014 5
2015 2
2016 1
2020 2
2021 3
2023 1
2024 0

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23 results

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Page 1
Evidence for dimeric BACE-mediated APP processing.
Jin S, Agerman K, Kolmodin K, Gustafsson E, Dahlqvist C, Jureus A, Liu G, Fälting J, Berg S, Lundkvist J, Lendahl U. Jin S, et al. Among authors: falting j. Biochem Biophys Res Commun. 2010 Feb 26;393(1):21-7. doi: 10.1016/j.bbrc.2010.01.064. Epub 2010 Jan 25. Biochem Biophys Res Commun. 2010. PMID: 20097169
Elevated soluble amyloid beta protofibrils in Down syndrome and Alzheimer's disease.
Johannesson M, Sahlin C, Söderberg L, Basun H, Fälting J, Möller C, Zachrisson O, Sunnemark D, Svensson A, Odergren T, Lannfelt L. Johannesson M, et al. Among authors: falting j. Mol Cell Neurosci. 2021 Jul;114:103641. doi: 10.1016/j.mcn.2021.103641. Epub 2021 Jun 4. Mol Cell Neurosci. 2021. PMID: 34091073
Reduction of brain stem pathology and transient amelioration of early cognitive symptoms in transgenic mice treated with a monoclonal antibody against α-synuclein oligomers/protofibrils.
Ekmark-Lewén S, Aniszewska A, Molisak A, Gumucio A, Lindström V, Kahle PJ, Nordström E, Möller C, Fälting J, Lannfelt L, Bergström J, Ingelsson M. Ekmark-Lewén S, et al. Among authors: falting j. Aging Brain. 2023 Jul 30;4:100086. doi: 10.1016/j.nbas.2023.100086. eCollection 2023. Aging Brain. 2023. PMID: 37559953 Free PMC article.
ABBV-0805, a novel antibody selective for soluble aggregated α-synuclein, prolongs lifespan and prevents buildup of α-synuclein pathology in mouse models of Parkinson's disease.
Nordström E, Eriksson F, Sigvardson J, Johannesson M, Kasrayan A, Jones-Kostalla M, Appelkvist P, Söderberg L, Nygren P, Blom M, Rachalski A, Nordenankar K, Zachrisson O, Amandius E, Osswald G, Moge M, Ingelsson M, Bergström J, Lannfelt L, Möller C, Giorgetti M, Fälting J. Nordström E, et al. Among authors: falting j. Neurobiol Dis. 2021 Dec;161:105543. doi: 10.1016/j.nbd.2021.105543. Epub 2021 Nov 1. Neurobiol Dis. 2021. PMID: 34737044 Free article.
Core refinement toward permeable β-secretase (BACE-1) inhibitors with low hERG activity.
Ginman T, Viklund J, Malmström J, Blid J, Emond R, Forsblom R, Johansson A, Kers A, Lake F, Sehgelmeble F, Sterky KJ, Bergh M, Lindgren A, Johansson P, Jeppsson F, Fälting J, Gravenfors Y, Rahm F. Ginman T, et al. Among authors: falting j. J Med Chem. 2013 Jun 13;56(11):4181-205. doi: 10.1021/jm3011349. Epub 2013 May 20. J Med Chem. 2013. PMID: 23126626
New aminoimidazoles as β-secretase (BACE-1) inhibitors showing amyloid-β (Aβ) lowering in brain.
Gravenfors Y, Viklund J, Blid J, Ginman T, Karlström S, Kihlström J, Kolmodin K, Lindström J, von Berg S, von Kieseritzky F, Bogar K, Slivo C, Swahn BM, Olsson LL, Johansson P, Eketjäll S, Fälting J, Jeppsson F, Strömberg K, Janson J, Rahm F. Gravenfors Y, et al. Among authors: falting j. J Med Chem. 2012 Nov 8;55(21):9297-311. doi: 10.1021/jm300991n. Epub 2012 Oct 3. J Med Chem. 2012. PMID: 23017051
23 results