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Modulating the strength of hydrogen bond acceptors to achieve low Caco2 efflux for oral bioavailability of PARP inhibitors blocking centrosome clustering.
Gu C, Lamb ML, Johannes JW, Sylvester MA, Eisman MS, Harrison RA, Hu H, Kazmirski S, Mikule K, Peng B, Su N, Wang W, Ye Q, Zheng X, Lyne PD, Scott DA. Gu C, et al. Among authors: eisman ms. Bioorg Med Chem Lett. 2016 Oct 1;26(19):4775-4780. doi: 10.1016/j.bmcl.2016.08.030. Epub 2016 Aug 12. Bioorg Med Chem Lett. 2016. PMID: 27578247
Ultra-low exposure to α-7 nicotinic acetylcholine receptor partial agonists elicits an improvement in cognition that corresponds with an increase in α-7 receptor expression in rodents: implications for low dose clinical efficacy.
Werkheiser JL, Sydserff S, Hubbs SJ, Ding M, Eisman MS, Perry D, Williams AJ, Smith JS, Mrzljak L, Maier DL. Werkheiser JL, et al. Among authors: eisman ms. Neuroscience. 2011 Jul 14;186:76-87. doi: 10.1016/j.neuroscience.2011.04.033. Epub 2011 Apr 24. Neuroscience. 2011. PMID: 21550383
-(S)-Alpha-phenyl-2-pyridine-ethanamine Dihydrochloride-, a low affinity uncompetitive N-methyl-D-aspartic acid antagonist, is effective in rodent models of global and focal ischemia.
Cregan EF, Peeling J, Corbett D, Buchan AM, Saunders J, Auer RN, Gao M, Mccarthy DJ, Eisman MS, Campbell TM, Murray RJ, Stagnitto ML, Palmer GC. Cregan EF, et al. Among authors: eisman ms. J Pharmacol Exp Ther. 1997 Dec;283(3):1412-24. J Pharmacol Exp Ther. 1997. PMID: 9400017