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N-(4-((2-(trifluoromethyl)-3-hydroxy-4-(isobutyryl)phenoxy)methyl)benzyl)-1-methyl-1H-imidazole-4-carboxamide (THIIC), a novel metabotropic glutamate 2 potentiator with potential anxiolytic/antidepressant properties: in vivo profiling suggests a link between behavioral and central nervous system neurochemical changes.
Fell MJ, Witkin JM, Falcone JF, Katner JS, Perry KW, Hart J, Rorick-Kehn L, Overshiner CD, Rasmussen K, Chaney SF, Benvenga MJ, Li X, Marlow DL, Thompson LK, Luecke SK, Wafford KA, Seidel WF, Edgar DM, Quets AT, Felder CC, Wang X, Heinz BA, Nikolayev A, Kuo MS, Mayhugh D, Khilevich A, Zhang D, Ebert PJ, Eckstein JA, Ackermann BL, Swanson SP, Catlow JT, Dean RA, Jackson K, Tauscher-Wisniewski S, Marek GJ, Schkeryantz JM, Svensson KA. Fell MJ, et al. Among authors: chaney sf. J Pharmacol Exp Ther. 2011 Jan;336(1):165-77. doi: 10.1124/jpet.110.172957. Epub 2010 Oct 14. J Pharmacol Exp Ther. 2011. PMID: 20947638
MDL 27,531 selectively reverses strychnine-induced seizures in mice.
Kehne JH, Kane JM, Miller FP, Ketteler HJ, Braun DL, Senyah Y, Chaney SF, Abdallah A, Dudley MW, Ogden AM, et al. Kehne JH, et al. Among authors: chaney sf. Br J Pharmacol. 1992 Aug;106(4):910-6. doi: 10.1111/j.1476-5381.1992.tb14434.x. Br J Pharmacol. 1992. PMID: 1327393 Free PMC article.
The 5-hydroxytryptamine2A receptor antagonist R-(+)-alpha-(2,3-dimethoxyphenyl)-1-[2-(4-fluorophenyl)ethyl-4-piperidinemethanol (M100907) attenuates impulsivity after both drug-induced disruption (dizocilpine) and enhancement (antidepressant drugs) of differential-reinforcement-of-low-rate 72-s behavior in the rat.
Ardayfio PA, Benvenga MJ, Chaney SF, Love PL, Catlow J, Swanson SP, Marek GJ. Ardayfio PA, et al. Among authors: chaney sf. J Pharmacol Exp Ther. 2008 Dec;327(3):891-7. doi: 10.1124/jpet.108.143370. Epub 2008 Sep 4. J Pharmacol Exp Ther. 2008. PMID: 18772320
Preclinical characterization of the potential of the putative atypical antipsychotic MDL 100,907 as a potent 5-HT2A antagonist with a favorable CNS safety profile.
Kehne JH, Baron BM, Carr AA, Chaney SF, Elands J, Feldman DJ, Frank RA, van Giersbergen PL, McCloskey TC, Johnson MP, McCarty DR, Poirot M, Senyah Y, Siegel BW, Widmaier C. Kehne JH, et al. Among authors: chaney sf. J Pharmacol Exp Ther. 1996 May;277(2):968-81. J Pharmacol Exp Ther. 1996. PMID: 8627580
Cyclic nitrone free radical traps: isolation, identification, and synthesis of 3,3-dimethyl-3,4-dihydroisoquinolin-4-ol N-oxide, a metabolite with reduced side effects.
Thomas CE, Bernardelli P, Bowen SM, Chaney SF, Friedrich D, Janowick DA, Jones BK, Keeley FJ, Kehne JH, Ketteler B, Ohlweiler DF, Paquette LA, Robke DJ, Fevig TL. Thomas CE, et al. Among authors: chaney sf. J Med Chem. 1996 Dec 6;39(25):4997-5004. doi: 10.1021/jm960244n. J Med Chem. 1996. PMID: 8960560