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Polymorphic variants of cytochrome P450 2B6 (CYP2B6.4-CYP2B6.9) exhibit altered rates of metabolism for bupropion and efavirenz: a charge-reversal mutation in the K139E variant (CYP2B6.8) impairs formation of a functional cytochrome p450-reductase complex.
Zhang H, Sridar C, Kenaan C, Amunugama H, Ballou DP, Hollenberg PF. Zhang H, et al. Among authors: amunugama h. J Pharmacol Exp Ther. 2011 Sep;338(3):803-9. doi: 10.1124/jpet.111.183111. Epub 2011 Jun 9. J Pharmacol Exp Ther. 2011. PMID: 21659470 Free PMC article.