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Page 1
Design of polyamine-based therapeutic agents: new targets and new directions.
Essays Biochem. 2009 Nov 4;46:77-94. doi: 10.1042/bse0460006.
Essays Biochem. 2009.
PMID: 20095971
Free PMC article.
Review.
Mechanism-based inactivation of cytochrome P450 2B6 by methadone through destruction of prosthetic heme.
Amunugama HT, Zhang H, Hollenberg PF.
Amunugama HT, et al.
Drug Metab Dispos. 2012 Sep;40(9):1765-70. doi: 10.1124/dmd.112.045971. Epub 2012 Jun 8.
Drug Metab Dispos. 2012.
PMID: 22685215
Free PMC article.
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Mechanism-based inactivation of human cytochrome P450 2B6 by clopidogrel: involvement of both covalent modification of cysteinyl residue 475 and loss of heme.
Zhang H, Amunugama H, Ney S, Cooper N, Hollenberg PF.
Zhang H, et al. Among authors: amunugama h.
Mol Pharmacol. 2011 Nov;80(5):839-47. doi: 10.1124/mol.111.073783. Epub 2011 Aug 23.
Mol Pharmacol. 2011.
PMID: 21862689
Free PMC article.
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Polymorphic variants of cytochrome P450 2B6 (CYP2B6.4-CYP2B6.9) exhibit altered rates of metabolism for bupropion and efavirenz: a charge-reversal mutation in the K139E variant (CYP2B6.8) impairs formation of a functional cytochrome p450-reductase complex.
Zhang H, Sridar C, Kenaan C, Amunugama H, Ballou DP, Hollenberg PF.
Zhang H, et al. Among authors: amunugama h.
J Pharmacol Exp Ther. 2011 Sep;338(3):803-9. doi: 10.1124/jpet.111.183111. Epub 2011 Jun 9.
J Pharmacol Exp Ther. 2011.
PMID: 21659470
Free PMC article.
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